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Updated: May 2, 2026

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
05:01

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Published on: August 16, 2019

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[在纳瓦拉 (西班牙) 严重创伤伤害模式的分析 (2010-2019) ]

Eider Arbizu Fernández1, Arkaitz Galbete Jimenez2, Tomás Belzunegui Otano3

  • 1Servicio Navarro de Salud-Osasunbidea. Hospital Universitario de Navarra. Servicio de Urgencias Generales. Pamplona. España. eider.arbizu@gmail.com.

Anales del sistema sanitario de Navarra
|September 3, 2024
PubMed
概括

这项研究分析了纳瓦拉的主要创伤病例,揭示了性别和死亡率群体之间受伤模式的显著差异. 了解这些创伤人口统计数据对于改善患者的治疗结果至关重要.

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Traumatic Brain Injury l: Introduction01:28

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DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
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Secondary Spinal Cord Injury llI: Pathophysiology01:25

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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
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