在儿童年轻时关闭心房隔膜缺陷对左心室功能有益
Pia Sjöberg1,2, Henning Clausen3,4, Håkan Arheden1,2
1Clinical Physiology, Department of Clinical Sciences, Lund, Lund University, Box 188, 221 00 Lund, Sweden.
European heart journal. Imaging methods and practice
|September 3, 2024
概括
在儿童中,心房隔膜缺陷 (ASD) 关闭改善左心室 (LV) 功能和血液动力学. 然而,LV数量仍然小于封闭后的控制,这可能会影响长期结果.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 心血管生理学心血管生理学
- 医疗成像医学成像
背景情况:
- 前庭隔膜缺陷 (ASD) 导致右心室体积过载.
- 自闭症的关闭并不总是解决症状或改善运动能力,这表明潜在的左心室 (LV) 血液动力学影响.
研究的目的:
- 评估ASD关闭对儿童非侵入性LV压力-体积 (PV) 循环的影响.
- 为了比较患有自闭症的儿童在关闭前和关闭后与健康对照的LV血液动力学.
主要方法:
- 用心磁共振 (CMR) 成像和臂血压来获得非侵入性的LV PV环.
- 23名患有自闭症的儿童接受了CMR,其中17名在关闭后重新接受了检查;包括12名对照组.
主要成果:
- 在ASD关闭后,LV终端透析体积增加,但仍然小于对照组.
- 与对照组相比,患有自闭症儿童的起始值收缩率和动脉弹性较高.
- 关闭后,收缩性和动脉弹性下降,接近对照水平.
结论:
- 患有自闭症儿童的左心室 (LV) 尽管处于分流,但仍然具有血液动力学效率.
- 由于心室合规性,早期ASD关闭对LV功能有益.
- 关闭后持续的小LV体积可能会影响长期的心血管风险和运动表现.
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