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人类牛奶的宏观和微量元素:同时通过ICP-MS进行分毫升量分析,并用于评估急性补充效应

Daniela Hampel^1,2, M Munirul Islam³, Setareh Shahab-Ferdows²

¹Institute for Global Nutrition, Department of Nutrition, University of California, Davis, CA, 95616, USA.

|September 3, 2024

概括

准确分析母乳营养素对婴儿健康至关重要. 一种新方法精确地在小样本中测量了13个元素,揭示了纯母乳养婴儿的补充效应和潜在缺陷.

科学领域:

营养生物化学营养生物化学
分析化学分析化学
儿童营养学儿童营养学

背景情况:

人母乳 (HM) 营养分析对于纯母乳养 (EBF) 婴儿生长至关重要.
现有的HM宏观和微量元素分析方法通常很复杂,需要大量的样本.
准确的监测对于识别缺陷和评估营养干预措施至关重要.

研究的目的:

开发和验证一种全面的,同时用于分析母乳中的13种宏观和微量元素的方法.
评估方法的准确性,精度和样本体积要求.
调查补充剂对HM营养度的影响,并确定潜在的缺陷.

主要方法:

100-600μL HM的微波消化用酸进行.
感应合等离子体质谱法 (ICP-MS) 具有H-动能差异化 (KED) 和O2-动态反应电池 (DRC) 模式.
使用NIST SRM 1869婴儿配方和分析孟加拉母亲的HM的验证.

主要成果:

该方法使用亚毫升HM样本准确量化了13个元素,精度高 (CV:2.8-8.5%).
补充后的分析显示 (P), (Ca) 和 (Zn) 的度增加 (p < 0.05).
(Na), (Mg), (Zn) 和 (Se) 的含量经常低于充足的摄入量.

结论:

一种经过验证,敏感的方法使得在小HM卷中同时分析多个元素.
补充剂可以选择性地增加某些HM营养水平.
在HM中低度的必需元素如Na,Mg,Zn和Se对EBF婴儿构成风险.

关键词:

孟加拉国孟加拉国孟加拉国人类的牛奶是人类的牛奶.在ICP-MS中,使用的是ICP-MS.这些是宏观元素.孕产妇补充产妇补充微量元素微量元素

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