根据"罗马IV":一项病例对照研究,患有炎症性肠病的患者中胃肠功能障碍的相对频率
Maryam Soheilipour1, Tahereh Ghasemi Chermahini1, Babak Tamizifar1
1Isfahan Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Advanced biomedical research
|September 3, 2024
概括
功能性消化不良 (FD) 影响炎症性肠病 (IBD) 患者与健康个体相似. 然而,刺激性肠综合征 (IBS) 症状在IBD患者中更为普遍,这表明罗马IV IBS和FD之间存在潜在的重叠.
科学领域:
- 胃肠病学 胃肠病学
- 消化系统健康 消化系统健康
- 临床研究 临床研究
背景情况:
- 炎症性肠病 (IBD) 显著破坏消化功能,并且可以与其他胃肠道疾病并存.
- 功能性消化不良 (FD) 是一种降低生活质量并带来诊断挑战的疾病.
- 调查IBD患者的FD患病率对于了解患者的并发症至关重要.
研究的目的:
- 确定诊断为炎症性肠病 (IBD) 的患者功能性消化不良 (FD) 的相对频率.
- 将IBD队列中的FD患病率与健康对照组进行比较.
- 在IBD患者中探索FD和易怒肠综合征 (IBS) 之间的潜在重叠.
主要方法:
- 采用了病例控制研究设计,招募了100名IBD患者和100名健康对照.
- 功能性消化不良 (FD) 症状使用ROME IV标准对所有参与者进行了评估.
- 统计分析包括奇平方和t测试,具有P ≤0.05的显著性水平.
主要成果:
- 在IBD患者中,FD的患病率为10%,在健康对照组中为5%,没有统计学上显著的差异 (P > 0.05).
- 刺激性肠综合征 (IBS) 的症状,特别是腹痛和改变的肠道运动,在IBD患者中明显更常见 (P = 0.01,P = 0.02).
结论:
- 功能性消化不良 (FD) 症状在炎症性肠病 (IBD) 患者中并不比健康对照群更频繁.
- 刺激性肠综合征 (IBS) 症状在IBD患者中显著升高,表明可能与FD标准重叠.
- 进一步的研究可能会澄清罗马四号IBS和FD在IBD的背景下之间的关系和诊断重叠.
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