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强化口腔预防不改变慢性病的年轻患者的舌头微生物组:纵向,随机,受控研究
Karolin C Hoefer1, Lutz T Weber2, Anna Greta Barbe1
1Faculty of Medicine and University Hospital of Cologne, Polyclinic of Operative Dentistry and Periodontology, University of Cologne, Cologne, Germany.
Frontiers in immunology
|September 3, 2024
概括
一个密集的口腔预防计划没有改变慢性病 (CKD) 儿童的舌头微生物组. 该研究发现,尽管进行了牙科干预,但舌头微生物组保持稳定,并且在CKD患者中改善了口腔健康.
科学领域:
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學.
- 儿科牙科 儿科牙科
背景情况:
- 牙炎在儿科慢性病 (CKD) 患者中很常见,具有跨学科的挑战.
- 舌头微生物组在CKD患者口腔健康中的作用尚未完全理解.
研究的目的:
- 为了研究强化口腔预防计划 (OPP) 与标准护理对牙炎的年轻CKD患者的舌头微生物群的影响.
主要方法:
- 纳入了30名患有牙炎的儿科慢性病患者.
- 在基线,3个月和6个月收集了舌头拭子.
- 16S rDNA基因测序分析了微生物群落,将密集的OPP与常规治疗 (TAU) 进行比较.
主要成果:
- 在任何时间点,在OPP和TAU组之间没有观察到微生物丰富性,丰富性或多样性的显著差异.
- 虽然Firmicutes在TAU组下降,但在OPP组中这种变化并不显著.
- 没有检测到预定义的牙炎或口腔健康细菌集群的变化.
结论:
- 密集的牙科预防没有导致儿科CKD患者舌头微生物组的临床相关变化.
- 舌头微生物组看起来是保存和稳定的,即使在患有CKD和牙炎的儿童中也是如此.
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