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身体活动,久坐不动的行为和败血症的风险:一项两样本的门德尔随机化研究

Yang Zhang^1,2, Yu Rong^1,3, Jun Mao^1,3

¹The Second Department of Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Frontiers in medicine

|September 3, 2024

概括

参与中度至剧烈的体力活动 (MVPA) 和剧烈的体力活动 (VPA) 可能会降低败血症的风险. 相反,长时间的久坐行为,如驾驶,与毒症的风险更高有关.

科学领域:

遗传学是一个遗传学.
流行病学流行病学
公共卫生公共卫生

背景情况:

败血症是一种危及生命的疾病,对公共健康有重大影响.
身体活动和久坐不动行为在败血症风险中的作用需要进一步阐明.
了解可修改的风险因素对于制定有效的预防策略至关重要.

研究的目的:

调查身体活动,久坐行为和败血症风险之间的潜在因果关系.
评估不同体力活动强度和久坐行为与败血症发病率的关联.
为基于生活方式的败血症预防提供证据.

主要方法:

采用两样本的门德尔随机化方法,使用来自英国生物银行和FinnGen的大规模全基因组关联研究数据.
评估了基因预测的身体活动 (MVPA,VPA) 和久坐行为 (驾驶,使用计算机,看电视) 与败血症风险之间的关联.
使用逆方差加权,加权中位数和MR-Egger方法进行因果推断,并进行全面的灵敏度分析.

主要成果:

中度至剧烈的体力活动 (MVPA) 与败血症风险有显著的反向关联 (OR 0.47,P=0.0296).
剧烈的体力活动 (VPA) 也与败血症风险相关 (OR 0.19,P=0.0324).
长时间的驾驶时间与增加的败血症风险有显著的积极关联 (OR 3.99,P=0.0097).

结论:

这项研究表明,MVPA和VPA对败血症有因果保护作用.
长时间的久坐行为,特别是驾驶,可能会因果性地增加败血症风险.
这些发现支持发展身体活动干预措施,以预防败血症.

关键词:

门德尔的随机化是门德尔的随机化身体活动身体活动危险的风险危险的风险没有久坐的行为.这是一种血症.

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