临床管理的小细胞扩散癌症:应用多学科瘤委员会建议在实践中
Sebastian M Christ1, Minsu Breitenstein2, Philip Heesen2
1Dept. of Radiation Oncology, University Hospital & University of Zurich, Zurich, CH, Switzerland.
Clinical and translational radiation oncology
|September 3, 2024
概括
多学科瘤委员会 (MDTs) 确保优质的癌症护理. 对寡头转移性疾病 (OMD) 的MDT建议的遵守率很高 (83.7%),但主要的偏差影响了整体存活率.
科学领域:
- 在瘤学瘤学.
- 癌症护理 癌症护理
- 临床决策 临床决策
背景情况:
- 多学科瘤委员会 (MDTs) 对于基于证据的个性化癌症治疗至关重要.
- 评估在寡头转移性疾病 (OMD) 中遵守MDT建议对于优化患者的治疗结果至关重要.
研究的目的:
- 评估在被诊断患有寡头转移性疾病 (OMD) 的患者中遵守和执行MDT建议.
- 确定与MDT建议的偏差相关的因素及其对整体存活时间 (OS) 的影响.
主要方法:
- 综合癌症中心从2020年开始对瘤PET扫描进行回顾性审查.
- 纳入标准:基于成像的OMD来自固体器官恶性瘤,MDT讨论,以及中心的随访.
- 偏差的分类:"重大" (从推治疗转变) 和"轻微" (对推治疗进行调整).
主要成果:
- 在787个确诊的OMD病例中,有347个 (44.1%) 在MDT讨论,331个 (42.1%) 接受治疗和跟踪.
- 总体上,对MDT建议的遵守率为83.7%.
- 大幅偏差发生在16.3%的病例中,最常见的是没有进行推治疗. 转移数量的增加 (>1) 与重大偏差 (OR:1.85) 有关. 主要偏差显著恶化了OS (p=0.0034).
结论:
- 在OMD患者中,对MDT建议的坚持通常很高.
- 从MDT计划的主要偏差与较差的整体存活率有关.
- 对患者特征和偏好进行更深入的讨论可能会进一步减少偏差.
更多相关视频
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
10.4K
07:44Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
Published on: March 12, 2018
10.1K
相关概念视频
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Cancer Survival Analysis
334
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
334
Tumor Immunotherapy
493
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
493
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
