在血动力学不稳定的骨盆骨折中静血干预和全因死亡率:系统性审查和元分析
XuWen Zheng1, MaoBing Chen1, Yi Zhuang1
1Truama Center Wujin People's Hospital Affiliated with Jiangsu University and Wujin Clinical College of Xuzhou Medical University, Changzhou 213017, China.
Emergency medicine international
|September 3, 2024
概括
外部固定 (EF),动脉栓塞 (AE) 和腹膜外包装 (EPP) 降低了血液动力学不稳定的骨盆骨折的死亡率. 复苏性内血管气球阻塞大动脉 (REBOA) 增加死亡率.
科学领域:
- 创伤外科 手术 创伤外科
- 关键护理医学 关键护理医学
- 紧急医疗 紧急医疗
背景情况:
- 血液动力学不稳定的骨盆骨折与高死亡率有关.
- 有效的静血疗法对于患者的生存至关重要.
- 各种干预措施旨在控制这些关键病例的出血.
研究的目的:
- 系统地审查和分析与血液动力学不稳定的骨盆骨折常见的静血治疗相关的全因死亡率.
主要方法:
- 在PubMed,Embase,Web of Science和Cochrane数据库中进行了全面的搜索,截至2023年4月30日.
- 分析包括报告概率比率 (OR) 或计算其数据的研究.
- 普洛斯佩罗的注册号码是:CRD42023421137. 这里是我们的注册号.
主要成果:
- 外部固定 (EF),动脉栓塞 (AE) 和腹膜外包装 (EPP) 与显著降低的死亡率有关 (ORs < 1).
- 复苏性内血管气球关闭大动脉 (REBOA) 与死亡率增加有关 (OR > 1).
- 在AE和EPP之间没有发现明显的死亡率差异作为初始治疗 (OR = 0.910,95%CI = 0.623-1.328).
结论:
- 建议EF,AE和EPP作为血液动力学不稳定的骨盆骨折的救生程序.
- 在这种患者群体中,REBOA可能与死亡率的增加有关.
- 进一步的研究可能会澄清这些干预措施的最佳顺序和组合.
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