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在多发性硬化症和神经炎光学谱障碍患者的眼部变化的比较

Xiaoyue Wang¹, Li Bao¹

¹Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Frontiers in neurology

|September 3, 2024

概括

光学连贯断层扫描 (OCT) 和视觉唤起潜能 (VEP) 在多发性硬化症 (MS) 和神经脊髓炎光谱障碍 (NMOSD) 患者中显示出明显的眼睛变化,有助于疾病监测和分化.

科学领域:

眼科医生眼科眼科
神经科学是一个神经科学.
免疫学免疫学免疫学

背景情况:

多发性硬化症 (MS) 和神经脊髓炎光学谱障碍 (NMOSD) 是影响中枢神经系统的炎症性脱髓化疾病.
眼部表现在MS和NMOSD中都是常见的,但区分它们可能具有挑战性.
先进的成像和电生理学技术为详细的眼睛评估提供了潜力.

研究的目的:

通过光谱域光学一致性断层扫描 (SD-OCT) 和模式视觉唤起潜力 (PVEP) 分析,研究和比较MS和NMOSD患者的眼睛变化.
为了确定特定的视网膜和视神经变化表明每个疾病.

主要方法:

追溯分析了82名多发性硬化患者的164只眼睛,59名NMOSD患者的118只眼睛和50名健康对照患者的100只眼睛.
SD-OCT用于测量视网膜神经纤维层 (RNFL) 厚度和质细胞内状层 (GCIPL) 厚度.
使用PVEP来评估P100的延迟和振幅.

主要成果:

无论是NMOSD还是MS患者,与没有光神经炎的患者相比,光神经炎患者的眼睛中GCIPL厚度和P100幅度都降低了.
在患有视神经炎的眼睛中,与MS患者相比,NMOSD患者表现出较薄的时间和高级RNFL和较薄的GCIPL.
在没有视神经炎的眼睛中,MS患者的鼻腔RNFL比NMOSD患者更薄.

结论:

SD-OCT和PVEP是监测和区分MS和NMOSD病理变化的宝贵工具.
特定的RNFL和GCIPL稀释模式,以及PVEP变化,可以帮助区分MS和NMOSD.

关键词:

多发性硬化症多发性硬化症神经脊髓炎光学谱系障碍眼部的变化眼部的变化频谱域光学连贯性断层扫描频谱域光学连贯性断层扫描视觉唤起的潜在潜力

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