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肌肉侵入性膀癌的膀节省选择
Ekaterina Laukhtina1, Marco Moschini2, Jeremy Yuen-Chun Teoh3
1Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Current opinion in urology
|September 3, 2024
概括
膀节约治疗为选择肌肉侵入性膀癌 (MIBC) 患者提供了激进囊切除术的有希望的替代方案. 研究正在推进治疗方案和患者选择,以改善生活质量.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
背景情况:
- 肌肉侵入性膀癌 (MIBC) 传统上需要进行激进囊切除术 (RC).
- 膀保护策略正在成为选择患者的替代方案.
研究的目的:
- 批判性地评估MIBC当前的膀节省选择.
- 概述未来的膀保护研究方向.
主要方法:
- 对MIBC的膀节约治疗方法的当前文献的综述.
- 对三模治疗 (TMT) 和组合治疗方法的结果分析.
主要成果:
- 膀节约治疗,包括TMT,在精心挑选的MIBC患者中显示出与RC相似的结果.
- 将免疫疗法与传统治疗相结合,产生了有前途的结果.
- 目前正在进行的研究重点是优化反应评估的协议,药物输送和生物标志物.
结论:
- 膀保存为精选的MIBC患者提供了RC的可行替代方案,可能改善生活质量.
- 优化患者选择,反应评估和救援策略至关重要.
- 预计膀保护在MIBC中的作用将随着证据的不断发展而扩大.
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