尿路微生物组的不断发展的世界
Hrishikesh Dalvi1, Nicole J De Nisco1,2
1Department of Biological Sciences, The University of Texas at Dallas, Richardson.
Current opinion in urology
|September 3, 2024
概括
尿路微生物组的组成随着年龄和性激素的变化而变化,影响尿路感染的易感性. 了解这些变化对于开发尿道病的新疗法至关重要.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 微生物学 微生物学
- 遗传学 是一个遗传学.
背景情况:
- 泌尿道不再被认为是无菌的,具有公认的微生物组.
- 尿路微生物组与泌尿道感染 (UTI),失禁和膀癌等泌尿病相关.
研究的目的:
- 审查最近关于尿路微生物组组成变化的发现.
- 探索与衰老的关联以及对尿路感染的易感性.
主要方法:
- 评论最近的科学文献.
- 对不同生命阶段和性别的尿道微生物组组成研究的分析.
主要成果:
- 尿路微生物组的组成因年龄和性激素而有显著变化.
- 在青春期前,生殖年龄和更年期后的女性中观察到不同的微生物组.
- 男性的尿路微生物群随着年龄和泌尿病史的变化而变化.
- 普遍存在的物种可能表明存在失生症.
- 新兴的研究探讨了尿路微生物群功能,遗传因素和尿病原体相互作用.
结论:
- 尿路微生物组是尿路疾病的潜在治疗点.
- 需要进一步的研究来了解它在开发基于微生物组的疗法方面的功能.
- 准确的动物模型的开发和宿主微生物群相互作用的探索对于未来的进展至关重要.
更多相关视频
07:34Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis
Published on: April 16, 2019
8.1K
08:53Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice
Published on: December 4, 2020
5.9K
相关概念视频
Urinary Bladder
487
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
487
Disorders of the Urinary System
266
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
266
Physiology of Urine Formation
3.4K
Urine formation is an essential function of the human body. It plays a critical role in maintaining homeostasis by regulating the volume and composition of body fluids. The kidneys, the primary organs involved in this process, filter blood to remove waste products and excess substances, ultimately producing urine.
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
3.4K
Introduction to Urinary System
2.3K
The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
2.3K
Filtration and Urine Formation
49.9K
The function of the kidneys is to filter, reabsorb, secrete, and excrete. Every day the kidneys filter nearly 180 liters of blood, initially removing water and solutes but ultimately returning nearly all filtrates into circulation with the help of osmoregulatory hormones. This process removes wastes and toxins but is also crucial to maintain water and electrolyte levels. Most of these functions are performed by the tiny but numerous nephrons contained within the kidneys.
49.9K
Ureters
403
The ureters are retroperitoneal tubes located on either side of the vertebral column. They are responsible for transporting urine from each kidney to the urinary bladder. These tubes have thick walls and are approximately 25-30 cm long. Their diameter is around 10 mm at the renal pelvis, gradually narrowing to 1 mm as the ureter obliquely enters the posterior bladder wall through the ureteric orifices. The shape of these orifices is slit-like, which helps to prevent urine backflow toward the...
403
