通过在无金属条件下进行三组分反应,轻松获得S-aryl/alkyl dithiocarbamates
Lin-Lin Xu1, Si-Ran Wang1, Jia-Qi Sun1
1National Engineering Research Center of Pesticide, College of Chemistry, Nankai University, Tianjin 300071, China. xudazhen@nankai.edu.cn.
Organic & biomolecular chemistry
|September 3, 2024
概括
这项研究提出了一种简单的,单一的方法,用于合成使用二硫化碳 (CS2),氨基和硫醇的dithiocarbamates等有机硫化合物. 这种环保的方法避免了催化剂,并有效地产生了各种各样的dithiocarbamates.
科学领域:
- 有机化学 有机化学
- 绿色化学 绿色化学
背景情况:
- 为有机硫化合物,特别是二硫化碳 (CS) 开发高效和原子经济的合成路径,仍然是有机合成的一个重大挑战.
- 现有的方法往往需要恶劣的条件,多个步骤或专门的试剂,从而限制了它们的实际应用.
研究的目的:
- 建立一个简单的,对环境无害的,用于合成S-aryl/alkyl dithiocarbamates的单协议.
- 通过使用易于获得的起始材料,演示一种新的三元合反应.
主要方法:
- 一种三组分反应,涉及烯/基醇,二硫化碳 (CS) 和氨基.
- 该反应是在水和N,N-二甲基胺 (H2O-DMAc, 3:1比率) 的混合溶剂系统中进行的,使用碳酸 (K2CO3) 作为基.
- 不需要外部催化剂或反应物的预功能化.
主要成果:
- 开发的方法成功合成了一系列具有多种结构特征的S-aryl/alkyl dithiocarbamates (aryl,alkyl,heteroaryl,alkenyl部分).
- 该协议在操作上简单,在温和条件下有效地进行,提供产品的良好产量.
- 反应表明高原子经济性,并利用环保条件.
结论:
- 成功开发了一种新的,绿色的,高效的单方法来合成S-aryl/alkyl dithiocarbamates.
- 该协议提供了一种实用且方便的替代方案,用于从CS2获取有价值的有机硫化合物.
- 该方法强调了在可持续有机合成中简单的基催化多组分反应的潜力.
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