在西澳大利亚各地接受高等保健的幼儿中呼吸道病毒检测率模式:以人口为基础的出生队列研究
Belaynew W Taye1,2, Mohinder Sarna1,2, Huong Le1,2
1Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, Australia.
Influenza and other respiratory viruses
|September 3, 2024
概括
在西澳大利亚,幼儿的呼吸系统病毒检测率因地点和年龄而异. 了解这些模式是准确估计RSV和流感等病毒的住院负担的关键.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 病毒学 病毒学
背景情况:
- 准确估计病原体特异性住院负担需要了解病毒检测率.
- 呼吸道综合性病毒 (RSV),流感病毒,偏流感病毒 (PIV) 和人类甲肺病毒 (hMPV) 是儿童呼吸系统疾病的重要原因.
研究的目的:
- 估计西澳大利亚5岁以下儿童的RSV,流感,PIV和hMPV的测试模式.
- 根据地理位置,年龄和时间段分析测试变化.
主要方法:
- 基于人口的队列研究,使用2010-2021年间的相关行政数据 (出生,死亡,住院,病毒监测).
- 使用生存分析技术来检查医院内测试率.
- 二元逻辑回归确定了测试的独立预测因素.
主要成果:
- 总共有46,553个测试对355,021名儿童进行了分析.
- 在2012年至2018年,婴儿的RSV测试率下降,然后增加,而非大都市的测试率普遍上升.
- 测试的关键预测因素包括12个月以下的年龄,早产 (<32周) 和远程居住.
结论:
- 目前的病毒检测率可能会导致低估呼吸道病毒住院的情况.
- 需要开发方法来估计呼吸道病毒入院的真实负担.
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