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在半球切除术前后的行为和大脑形态变化

Hao Yu¹, Yijun Chen², Ziyu Bao²

¹Pediatric Epilepsy Center, Peking University First Hospital, Beijing, China.

Human brain mapping

|September 3, 2024

概括

半球切除手术显示了大脑的变化,有助于儿童从中恢复. 在特定的大脑区域的灰质体积变化预测恢复,特别是在右侧手术后小脑中.

科学领域:

神经科学是一个神经科学.
神经外科神经外科
儿科神经学儿科神经学

背景情况:

半球切除术是一种成功的手术,用于扩散的单半球病变.
手术后的神经可塑性及其与半球切除术后行为恢复的联系尚不清楚.

研究的目的:

在左半球或右半球切除术后调查灰质体积 (GMV) 变化.
分析GMV变化与行为恢复之间的关系.
探索术前成像对术后结果的预测价值.

主要方法:

儿科患者手术前和后的GMV比较 (29左半球切除,28右半球切除).
使用2115名健康儿童的规范建模来推导年龄调整的GMV.
与行为评分相关的GMV变化.

主要成果:

两组都显示在对侧大脑和小脑侧侧脑部的GMV增加.
两组人都表现出对侧小脑的GMV下降.
左半球切除术患者独特地显示GMV在逆侧环状回形中减少.
与右半球切割患者的行为改善相关的逆侧小脑GMV降低.
在手术前的GMV预测了两组手术后的行为评分.

结论:

神经可塑性,特别是在对侧小脑中,在右半球切除术后的行为恢复中起作用.
术前脑成像可以预测儿科半球切割患者的术后行为结果.

关键词:

是一种.灰色物质的体积,灰色物质的体积.半球切除术 (hemispherotomy) 是一个半球切除术.磁共振成像技术的使用塑性的可塑性塑性

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