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Updated: Jun 14, 2025

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
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Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

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同时估计多克索鲁比辛和拜卡莱因的LC-MS/MS方法:配方和药理动力学应用

Pooja Yadav1,2, Sanjay Singh1, Divya Chauhan1,2

  • 1Division of Pharmaceutics & Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, 226031, India.

Nanomedicine (London, England)
|September 3, 2024
PubMed
概括

这项研究开发了一种新型纳米配方,用于联合多克索鲁比辛 (DOX) 和拜卡莱因 (BAC) 输送,以增强乳腺癌治疗并减少DOX诱导的心脏毒性. 药物动力学研究证实,纳米配方改善了药物暴露.

关键词:
德克索鲁比辛是一种多克索鲁比辛.同时估计的估计.巴伊卡莱因 (Baicalein) 是一种植物.生物分析方法 生物分析方法药物动力学 药物动力学自我纳米乳化纳米乳化.

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One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
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