代谢功能障碍和黑人心力衰竭亚型的发病率:杰克逊心脏研究
Arnaud D Kaze1, Alain G Bertoni2, Ervin R Fox3
1Department of Medicine, Division of Cardiology, Banner-University Medical Center Phoenix, The University of Arizona College of Medicine, Phoenix, AZ, USA.
European journal of heart failure
|September 3, 2024
概括
代谢综合征的严重程度显著增加了黑人心力衰竭的风险. 管理新陈代谢健康对于预防心力衰竭和心力衰竭都至关重要,以保持喷射分数和心力衰竭减少喷射分数.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 代谢综合征 (MetS) 是一组增加心脏病,中风和2型糖尿病风险的疾病.
- 在不同的人群中,MetS严重程度对亚临床心脏变化和心力衰竭 (HF) 发生率,特别是HF亚型的影响仍未得到充分研究.
- 黑人个体的MetS和HF负担不成比例,需要对特定人群进行研究.
研究的目的:
- 调查MetS严重程度与亚临床心肌重塑之间的关联.
- 评估MetS严重程度与HF发病率之间的关系,包括具有保留喷射率 (HFpEF) 的HF和具有减少喷射率 (HFrEF) 的HF.
- 为了检查这些协会,特别是在黑人群体中.
主要方法:
- 该研究分析了杰克逊心脏研究的4069名参与者的数据,没有先前存在的HF.
- 使用基于腰围 (MetS-Z-WC) 和体重指数 (MetS-Z-BMI) 的得分来评估MetS状态和严重程度.
- 与回声心脏学参数,心脏生物标志物 (hs-cTnI, BNP) 和发生的HF住院病例 (HFpEF, HFrEF) 的关联在12年的中位随访期间进行了评估.
主要成果:
- MetS严重程度与亚临床心脏重塑和心脏生物标志物升高相关.
- 在12年的时间里,319名参与者患上了HF. MetS与HF风险增加两倍 (HR 2.07) 有关.
- 较高的MetS-Z-WC四分位数显著增加了HF风险,与HFrEF (HR 1.69) 相比,HFpEF (Q4 vs. Q1 HR 4.94) 的关联明显更强.
结论:
- 代谢综合征的严重程度与黑人个体中HFpEF和HFrEF风险增加有显著关联.
- 这些发现强调了优化代谢健康在预防HF亚型方面的关键作用.
- 针对MetS干预措施可能是减少这一群体中高频差异的关键.
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