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关于hesperidin和naringin在阿尔茨海默病的保护作用的基本方法
Müjgan Kuşi1,2, Eda Becer3, Hafize Seda Vatansever4,5
1Faculty of Health Sciences, Department of Nutrition and Dietetics, Near East University, Nicosia, North Cyprus via Mersin 10, Turkey.
Nutritional neuroscience
|September 3, 2024
概括
类黄素hesperidin和naringin由于抗氧化和抗炎作用,显示出对阿尔茨海默病 (AD) 治疗的潜力. 需要进一步的研究来证实它们对病理和认知功能的治疗益处.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 生物化学 生化学
背景情况:
- 阿尔茨海默病 (AD) 是一种进展性神经退行性疾病,导致显著的认知能力下降和社会负担.
- 目前针对阿尔茨海默病的治疗策略,特别是针对陶积累的治疗策略,仍然有限.
- 类水果中丰富的黄素hesperidin和naringin在各种疾病模型中表现出多样化的生物活动.
研究的目的:
- 为了审查阿尔茨海默病的病理生理学.
- 总结赫斯佩里丁和纳林金对阿尔茨海默病相关病理机制的潜在影响.
- 探索这些黄类药物在阿尔茨海默病预防和治疗中的治疗影响.
主要方法:
- 文献综述综合了有关阿尔茨海默病的现有研究.
- 分析研究研究hesperidin和naringin的抗氧化和抗炎性质的研究.
- 对这些黄类药物对关键阿尔茨海默症病理,包括粉样β (Aβ) 和聚变的影响的证据的评估.
主要成果:
- 赫斯佩里丁和纳林丁具有重要的抗氧化和抗炎性质.
- 这些黄类药物可能对Aβ和α-synuclein聚合产生改善作用.
- 潜在的好处延伸到缓解tau病理和改善AD模型中的认知功能.
结论:
- 赫斯佩里丁和纳林丁显示出作为预防或治疗阿尔茨海默病的潜在药物具有前途.
- 它们的抗氧化和抗炎机制是它们观察到的效果的关键.
- 需要进一步的严格研究,以充分阐明它们在阿尔茨海默病中的治疗疗效和安全性.
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