相关实验视频
Updated: Jun 14, 2025

10:40
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
Published on: April 25, 2022
2.3K
利用基因编辑技术用于瘤微环境调制:一种新兴的抗癌战略
Shujun Feng1, Yu Zhang2, Yanyi Wang1
1College of Engineering and Applied Sciences, Nanjing University, 210023, Nanjing, China.
Chemistry (Weinheim an der Bergstrasse, Germany)
|September 3, 2024
概括
与纳米材料相结合的CRISPR-Cas基因编辑提供了一种精确有效的方法来修改瘤微环境 (TME). 这种方法有望克服传统癌症疗法的挑战,从而产生持久的抗癌效果.
科学领域:
- 在瘤学瘤学.
- 生物技术是生物技术.
- 纳米医学是一种纳米医学.
背景情况:
- 瘤微环境 (TME) 显著影响癌症进展,影响治疗疗效.
- 传统的癌症疗法面临着诸如耐药性和由于忽视TME相互作用而导致复发等局限性.
- 癌细胞动态地改变TME以支持它们的生长和攻击性.
研究的目的:
- 探索CRISPR-Cas基因编辑技术在操纵TME治疗癌症方面的潜力.
- 审查如何将CRISPR-Cas与纳米材料结合起来可以增强抗癌疗法.
- 检查CRISPR-Cas作为一种用于持久抗癌结果的变革性方法.
主要方法:
- 审查关于CRISPR-Cas技术及其在癌症研究中的应用的当前文献.
- 分析用于提供CRISPR-Cas组件的纳米材料策略.
- 对专注于对TME进行基因操纵的研究进行审查.
主要成果:
- 克里斯普尔-卡斯技术使得TME的精确基因修饰成为可能.
- 基于纳米材料的交付提高了CRISPR-Cas的精度,减少了副作用,并提高了用户友好性.
- 将TME基因定位为目标,为克服治疗挑战提供了一个有希望的策略.
结论:
- 基因编辑CRISPR-Cas,特别是当与纳米材料集成时,为重新编程TME提供了一个强大的工具.
- 这种创新方法具有巨大的潜力,可以克服传统癌症治疗的局限性.
- 通过CRISPR-Cas介导的TME操纵为可持续的癌症治疗提供了一个有前途的途径.
相关概念视频
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Tumor Immunotherapy
493
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
493
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Gene Therapy
25.3K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
25.3K

