沉强度,营养分配,大麻素产量和相关的转录档案在两种药物类型中的大麻化学变异中各不相同
Ricarda Jost1,2, Oliver Berkowitz1,2, Amelia Pegg1,2
1Australian Research Council Research Hub for Medicinal Agriculture, Department of Animal, Plant and Soil Sciences, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC 3086, Australia.
Journal of experimental botany
|September 3, 2024
概括
繁殖大麻 (Cannabis sativa L.) 的高含量大麻 (CBD) 导致酸盐过度积累,限制了生长和产量. 在低营养土壤中有益的祖先大麻特征阻碍了CBD主导品种的受保护种植.
科学领域:
- 植物科学 植物科学
- 农业科学 农业科学
- 遗传学 是一个遗传学.
背景情况:
- 大麻sativa L.具有不同的化学类型:大麻 (高CBD) 和药物类型 (高THC).
- 大麻品种被选为快速生长和非中毒化合物,而药物品种则被选为高THC.
- 了解化学型差异的遗传基础对于优化作物表现至关重要.
研究的目的:
- 为了研究进化大麻特征对药物类型大麻对植物性能的影响.
- 分析CBD主导和THC主导大麻化学变异中的营养吸收,生物质积累和基因表达.
- 确定影响营养恒温的遗传因素及其与植物特征的相关性.
主要方法:
- 对THC主导和CBD主导大麻化学变异的比较分析.
- 测量植物性能特征,包括水槽强度,生物质和营养吸收.
- RNA测序 (RNA-seq) 用于分析器官和化学物种特定的基因表达.
- 分析与酸盐和酸盐平衡和生长调节相关的基因.
主要成果:
- 含有THC的主导的化学变体表现出更高的沉降强度,更高的花生质量和需求驱动的营养吸收.
- 在CBD主导的化学变异中,酸盐在下沉器官中过度积累,减少了叶子中的碳和同化.
- 在CBD主导的化学变异中观察到有限的花生物质和大麻素产量.
- 基因表达分析揭示了营养恒温和生长调节基因的器官和化学物质特异性差异.
结论:
- 在CBD占主导地位的大麻中酸盐过度积累限制了整体产量,与THC占主导地位的类型的高效营养使用形成鲜明对比.
- 在低营养环境中有利的与营养感知和获取相关的祖先大麻特征可能会对保护种植中雌性花的发育和CBD产量产生负面影响.
- 旨在优化营养平衡的基因改造对于在受控环境中增强CBD生产至关重要.
相关概念视频
Factors Affecting Drug Response: Overview
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
Factors Influencing Drug Absorption: Physicochemical Parameters
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs
A drug's physicochemical properties fundamentally influence its metabolism. For instance, a drug's molecular size and shape critically determine its interaction with enzymes and transporters — larger drugs may face difficulty reaching enzyme active sites, altering their metabolic pathways. The pKa of a drug, which establishes its ionization state, can impact its solubility and absorption, thereby influencing metabolism.
The drug's acidity or basicity is essential in determining the metabolic...
The drug's acidity or basicity is essential in determining the metabolic...


