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怀孕期间PAX9 rs2073244和被动吸烟对新生儿低出生体重的相互作用:一个病例对照研究

Qun Lou¹, Sihan Wu¹, Jinhua Zhang¹

¹Xiamen Center for Disease Control and Prevention, Fujian, China.

International journal of environmental health research

|September 3, 2024

概括

PAX9 rs2073244基因变异,特别是AG/AA基因型,可能会增加全产新生儿低出生体重 (LBW) 的风险,特别是当与母亲被动吸烟暴露相结合时.

科学领域:

遗传学遗传学是一种遗传学.
环境健康环境健康
新生儿科学新生儿科学

背景情况:

低出生体重 (LBW) 是一个重要的全球健康问题.
遗传因素和环境暴露,如被动吸烟,都与LBW有关.
在LBW中PAX9 rs2073244等特定基因变异的作用需要进一步调查.

研究的目的:

为了研究PAX9 rs2073244多态和全期LBW之间的关联.
检查PAX9 rs2073244和室内被动吸烟暴露对LBW的综合影响.
评估LBW发展中的遗传易感性和环境因素之间的相互作用.

主要方法:

进行了一项1:2对照病例对照研究,对LBW新生儿和正常出生体重 (NBW) 的对照进行了对照.
进行了PAX9 rs2073244多态的基因定型.
评估了孕妇在怀孕期间暴露在室内被动吸烟的情况.

主要成果:

室内被动吸烟暴露在LBW组比NBW组更为普遍 (p=0.019).
PAX9 rs2073244的GG基因型与LBW风险降低 (OR=0.38) 和头周 (HC) 较小 (OR=0.44) 相关.
观察到rs2073244的AG/AA基因型和母亲的被动吸烟之间存在显著的添加相互作用,增加了LBW风险 (相对过度风险=10.679).

结论:

PAX9 rs2073244的AG/AA基因型可能会使得满期婴儿对LBW产生敏感性.
孕妇在怀孕期间被动吸烟的暴露是LBW的重要危险因素.
特定的PAX9 rs2073244基因型和母亲被动吸烟的组合增加了LBW的风险,突出了基因与环境的相互作用.

关键词:

低出生体重低出生体重在PAX9中,PAX9是PAX9.互动互动互动互动被动吸烟是一种被动吸烟.单个核酸的多态性.

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