关于Cu2+-Doped Brushite水泥的应用相关性质的新见解
Karla Spaeth1, Qaisar Nawaz2, Tatjana Schilling3
1GeoZentrum Nordbayern, Mineralogy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Journal of biomedical materials research. Part B, Applied biomaterials
|September 3, 2024
概括
用铜添加的布鲁希特骨水泥显示保持了机械性能和缓慢的离子释放,但缺乏抗菌作用和轻微影响细胞活力. 植物酸配方比酸配方具有优势.
科学领域:
- 生物材料科学 生物材料科学
- 材料化学 材料化学
- 生物医学工程 生物医学工程
背景情况:
- 用金属离子染布鲁希特水泥可以改善生物和物理化学性质.
- 铜 (Cu2+) 离子具有抗菌潜力,但在高度下可能具有细胞毒性.
- 治疗性骨需要生物相容性和足够的机械强度.
研究的目的:
- 为了研究用Cu2+合布鲁希特水泥的物理化学和生物特性.
- 与酸相比,评估 phytic 酸作为离子释放的设置减速剂的影响.
- 评估Cu2+兴奋剂对水泥注射能力,机械强度和细胞反应的影响.
主要方法:
- 用Cu2+添加β-三酸,单酸单水合物和植物酸添加布鲁希特水泥的制备.
- 对注射率和压力强度的评估.
- 在体外评估抗菌活性和细胞毒性使用MC3T3-E1细胞与化物样本.
- 与使用酸作为减速剂的水泥进行Cu2+离子释放配置的比较.
主要成果:
- 研究的水泥表现出良好的注射性和足够的压力强度用于应用.
- 无论Cu2+度如何,对测试的细菌菌株没有观察到抗菌作用.
- MC3T3-E1细胞的细胞活力倾向于随着水泥中的Cu2+度的增加而下降.
- 使用 phytic 酸的水泥显示出 Cu2+ 离子的稳定,缓慢释放,与基于酸的水泥的突发释放不同.
结论:
- 2+的注保持了布鲁希特水泥的物理化学特性和压力强度.
- 没有检测到Cu2+化水泥预期的抗菌作用,哺乳动物细胞活力受到轻微影响.
- 在潜在的治疗应用中,与酸配方相比,植物酸延迟水泥的缓慢离子释放被认为是有利的.
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