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缺乏eIF6可以调节肠道微生物群,减少全身炎症,缓解动脉样硬化
Zhenzhen Wang1, Shuai Yang2, Linglin Tong2
1Cancer Institute, Xuzhou Medical University, Xuzhou, China.
mSystems
|September 3, 2024
概括
eIF6缺乏和Lactobacillus acidophilus对动脉样硬化的影响. eIF6 缺乏通过改变肠道微生物群来减少动脉样硬化病变. 补充 Lactobacillus acidophilus 抑制炎症并改善肠道屏障功能,为动脉样硬化提供治疗策略.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 代谢过程中的代谢.
- 心血管科学 心血管科学
背景情况:
- 改变肠道微生物群的组成会影响免疫力和新陈代谢.
- 之前的研究将eIF6基因的淘汰与肠道菌群的变化联系在一起,特别是乳酸菌酸的增加.
- 在冠状动脉疾病 (CAD) 患者中观察到高的eIF6,RNASE3和RSAD2水平.
研究的目的:
- 调查乳酸菌在动脉样硬化的发病过程中的作用.
- 评估eIF6缺乏对小鼠模型中动脉样硬化发展的影响.
- 探索Lactobacillus acidophilus在减轻动脉样硬化的治疗潜力.
主要方法:
- 对CAD患者和健康对照者的转录组分析.
- 在正常和高脂肪饮食中使用ApoE-/-和ApoE-/-/eIF6+/-小鼠模型16周.
- 在小鼠模型中,通过口腔 gavage 给予 Lactobacillus acidophilus 和 lipopolysaccharide.
主要成果:
- 在ApoE-/-/eIF6+/-小鼠中,eIF6缺乏减少了动脉样硬化病变的形成.
- 微生物和代谢分析揭示了eIF6缺乏的小鼠中的有益细菌和改变的代谢概况.
- 乳酸菌酸的使用抑制了高脂肪饮食引起的炎症,减少了动脉样硬化病变,并改善了肠道屏障功能.
结论:
- 通过调节肠道微生物群和代谢物,eIF6 缺乏可以预防动脉样硬化.
- 乳酸菌酸通过减少炎症和增强肠道透性来减轻动脉样硬化病变.
- 针对特定的肠道微生物物种,如Lactobacillus acidophilus,是预防动脉样硬化的有希望的治疗策略.
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