电场大小在左背侧前额叶皮层对使用跨直流刺激的内在功能连接的变化的影响:一个随机交叉研究
Eunkyung Kim1,2, Seo Jung Yun1,3,4, Byung-Mo Oh1,3,5
1Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Journal of neuroscience research
|September 3, 2024
概括
阳横直流刺激 (tDCS) 改变了休息时的大脑活动,并可能保持休息状态功能连接 (rsFC). 左背侧前额皮层 (L-DLPFC) 的电场大小与rsFC变化相关.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 大脑刺激 大脑刺激
背景情况:
- 超直流刺激 (tDCS) 显示出可变的反应,部分原因在于对静止状态大脑活动和功能连接不清楚的影响.
- 了解tDCS如何影响静止状态功能连接 (rsFC) 对于优化治疗应用至关重要.
研究的目的:
- 调查tDCS电场 (E-field) 大小对静止状态大脑活动和L-DLPFC rsFC的影响.
- 探索个体电子场建模与大脑活动和连接性的观察变化之间的关系.
主要方法:
- 21名健康参与者接受了针对L-DLPFC的阳极或虚拟tDCS.
- 在刺激之前和之后进行脑成像 (活动fALFF,rsFC).
- 单个E字段被建模并与fALFF和rsFC变化相关联.
主要成果:
- 阳极tDCS增加了左侧正面中间前部区域的fALFF,并在中线前部区域减少了它.
- 假冒刺激导致整体rsFC显著下降,而阳道tDCS显示了适度的,不显著的变化.
- 在L-DLPFC,左下垂体和右侧视觉区域中,模拟的E场和rsFC变化之间发现了相关性.
结论:
- 单个会话的tDCS可以调节休息时的大脑活动,并可能有助于维持整体的rsFC.
- 目标L-DLPFC中的E场大小与近距离和远距离大脑区域的rsFC变化有关.
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