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Updated: Jun 16, 2026

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新型和高度选择性的SARS-CoV-2主要蛋白酶抑制剂的设计

Adi N R Poli1, Ian Tietjen2, Nitesh K Nandwana1

  • 1Medicinal Chemistry, The Wistar Institute, Philadelphia, Pennsylvania, USA.

Antimicrobial agents and chemotherapy
|September 3, 2024
PubMed
概括

一种针对SARS-CoV-2主要蛋白酶 (Mpro) 的新型仿抑制剂显示出对多种变异的强有力的抗病毒活性. 这种Mpro抑制剂在子中表现出体内有效性,并与remdesivir协同作用,为抗药性SARS-CoV-2提供了一个有前途的策略.

关键词:
这就是SARS-CoV-2病毒.佐西类药物的使用.类模仿分子的模仿.蛋白酶抑制剂是一种蛋白酶抑制剂.

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