Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Identifying the most recommended novel teaching strategy in orthopaedics education: a systematic review and network meta-analysis.

Frontiers in medicine·2026

Same author

CDCP1 allosterically regulates the AMPK α1 subunit to enhance fatty acid oxidation in osteoblasts.

Cellular & molecular biology letters·2025

Same author

The relationship between parity, delivery mode, maternal age at delivery, and bone mineral density: a cross-sectional study.

BMC pregnancy and childbirth·2025

Same author

GLUL mediates FOXO3 O-GlcNAcylation to regulate the osteogenic differentiation of BMSCs and senile osteoporosis.

Cell death and differentiation·2025

Same author

A case-control study based on the National Health and Nutrition Examination Survey to evaluate the effects of human papilloma virus on bone health in women.

BMC medicine·2025

Same author

Correction: Ortho-silicic Acid Plays a Protective Role in Glucocorticoid-Induced Osteoporosis via the Akt/Bad Signal Pathway In Vitro and In Vivo.

Biological trace element research·2025

Search research articles

相关实验视频

Updated: Jun 14, 2025

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

具有离子持续释放的多功能生物骨周,用于骨再生.

Junjie Mao¹, Zhenqian Sun^2,3, Shidong Wang⁴

¹Liquid-Solid Structural Evolution & Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University, Jinan, Shandong, 250061, P. R. China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|September 3, 2024

概括

一种具有生物活性玻璃纤维膜 (BGFM) 的新型生物骨周骨 (BP) 增强了骨的修复. 这种材料控制离子释放,促进M2巨细胞的两极分化,并刺激骨质生成和血管生成以加速骨再生.

关键词:

血管新生的产生.这是一种抗炎药,是一种抗炎药.生物活性玻璃纤维膜膜.生物骨周骨 (bionic periosteum) 是一种生物骨周骨.延迟的离子释放延迟的离子释放骨质发生过程 (osteogenesis)孔隙结构是多孔结构.

更多相关视频

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Published on: August 22, 2016

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

相关实验视频

Last Updated: Jun 14, 2025

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Published on: August 22, 2016

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

科学领域:

生物材料科学生物材料科学
组织工程是组织工程.
再生医学是一种再生医学.

背景情况:

骨缺陷带来了重大的临床挑战.
目前的骨移植替代品在促进再生方面存在局限性.
开发先进的生物材料来增强骨修复是至关重要的.

研究的目的:

设计和表征一种新的生物骨 (BP) - 生物活性玻璃纤维膜 (BGFM).
研究和离子对膜结构和离子释放谱的影响.
评估BP-BGFM在促进骨质生成和血管生成的疗效,在体外和体内.

主要方法:

使用电与和离子制造BP-BGFM.
纤维形态,孔隙结构和离子释放动力学的表征.
关于巨细胞两极分化和骨质分化的体外研究.
对参与骨修复的信号通路的生物信息学分析.
在老鼠形缺陷模型中的体内评估.

主要成果:

加入Mg2+和Zn2+改变了孔隙结构,减少了快速的离子释放,改善了降解.
BP-BGFM诱导了M2巨细胞的两极分化,创造了一个亲骨质的免疫微环境.
生物信息学分析确定了JAK-STAT信号通路对于BP介导的骨修复至关重要.
从BP-BGFM中缓慢释放的离子直接促进了骨质生分化和血管化.
生物骨周表现出显著的血管新生和骨质新生在老鼠骨缺陷模型中.

结论:

这种新型的生物骨周骨有效地控制离子释放,并增强骨再生.
BP-BGFM促进了有利的免疫反应和骨质生分化.
这种生物材料显示出通过增强血管新生和骨质新生加速骨修复的巨大潜力.