肺部微生物和宿主基因组特征作为预测早期腺癌的预后
Jun-Chieh J Tsay1,2,3, Fares Darawshy1,4,5, Chan Wang6
1Division of Pulmonary, Critical Care and Sleep Medicine, NYU Grossman School of Medicine, NYU Langone Health, New York, New York.
概括
通过未受影响的肺组织中的微生物和宿主基因组特征,可以预测肺腺癌复发风险. 这种方法对识别患有早期肺癌复发高风险的患者有希望.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 早期肺腺癌的复发是一个重大的临床挑战,复发后的生存时间有限.
- 目前,没有经过验证的生物标志物可以预测手术切除后的复发风险.
- 了解复发的潜在机制对于开发有效的预测策略至关重要.
研究的目的:
- 研究肺组织中微生物和宿主基因组特征的潜力,以预测早期肺腺癌的复发.
- 为了确定与瘤复发相关的特定微生物和宿主转录组形状.
主要方法:
- 分析16S rRNA基因测序和宿主RNA测序在瘤和邻近的未受影响肺样本中的91名患有早期肺腺癌的患者.
- 微生物和宿主基因组数据与5年瘤复发事件的相关性.
主要成果:
- 肺腺癌的复发与瘤 (Dialister,Prevotella) 和未受影响的肺样本 (Sphingomonas,Alloiococcus) 中明显的微生物丰富有关.
- 在未受影响的肺样本中的微生物和宿主基因组签名显示,与瘤样本相比,复发的相关性更强.
- 使用未受影响的肺样本的结合微生物/转录组模型实现了高预测性能 (AUC = 0.83).
结论:
- 肺腺癌的复发与未受影响的肺组织内的特定微生物与宿主相互作用有关,而不是仅在切除的瘤内.
- 在未受影响的肺组织中,微生物和宿主基因组签名具有重要的潜力,作为肺腺癌复发的预测生物标志物.
- 对这些微生物与宿主相互作用的进一步研究可能会揭示预防或管理肺癌复发的新型治疗点.
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