系统性荷尔蒙避孕的使用和自杀企图的风险:一个嵌套的病例控制研究
Elena Toffol1, Timo Partonen2, Oskari Heikinheimo3
1Department of Public Health, Clinicum, University of Helsinki, Helsinki, Finland. elena.toffol@helsinki.fi.
European journal of epidemiology
|September 3, 2024
概括
荷尔蒙避孕药 (HC) 的使用,特别是组合类型,并没有增加15-49岁女性自杀未遂的风险. 事实上,HC使用与没有精神病史的妇女的风险较低有关.
科学领域:
- 生殖健康 生殖健康
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 荷尔蒙避孕药 (HC) 和自杀企图风险之间的关联仍然不清楚.
- 之前的研究已经产生了不确的证据,需要进一步调查.
研究的目的:
- 评估各种类型的全身性HC与15-49岁女性自杀企图风险之间的关系.
- 提供基于证据的见解,关于HC关于心理健康结果的安全性.
主要方法:
- 芬兰的一项基于人口的队列研究 (n=587,823) 使用了2017年国家注册数据.
- 一个嵌套的病例控制设计与多变量条件后勤回归分析了与HC使用有关的自杀企图风险.
- 从2018年到2019年的随访期,观察了818起自杀企图.
主要成果:
- 总体而言,HC使用,包括组合激素避孕药,与不使用相比,没有增加自杀企图的风险 (OR 0.68).
- 在没有先前精神病史的女性中,当前HC使用,特别是乙烯 Estradiol 制剂,与降低风险相关 (OR 0.54).
- 经过调整后,仅含孕激素的药物与自杀企图风险无关.
结论:
- 目前使用荷尔蒙避孕药与生育年龄妇女自杀企图的风险增加无关.
- HC,特别是含有乙烯 Estradiol 的方法,可能与特定人群中自杀企图的风险降低有关.
- 研究结果支持HC在生育年龄妇女的一般人口中对自杀企图风险的安全性.
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