在自身免疫性疾病的进展和治疗中,从介质细胞干细胞 (MSC) 衍生出的外体非编码RNA; 一个更新的审查
Shireen Hamid Farhan1, Saade Abdalkareem Jasim2, Pooja Bansal3,4
1Biotechnology department, College of Applied Science, Fallujah University, Fallujah, Iraq.
Cell biochemistry and biophysics
|September 3, 2024
概括
介酶干细胞外体,特别是它们的非编码RNA (ncRNA),通过调节免疫系统,显示出治疗自身免疫性疾病 (AD) 的前景. 这项研究回顾了外体ncRNA趋势和AD的治疗应用.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 遗传学 是一个遗传学.
背景情况:
- 自免疫性疾病 (AD) 是由于免疫系统过度活跃而引起的.
- 外基因组,特别是来自间基因干细胞 (MSCs) 的外基因组,正在成为无细胞疗法,具有针对AD的免疫调节潜力.
- 外体非编码RNAs (ncRNAs),包括microRNAs (miRNAs) 和长非编码RNAs (lncRNAs),在健康和疾病中发挥关键作用.
研究的目的:
- 审查对自身免疫性疾病 (AD) 外体ncRNA的当前研究趋势.
- 探索MSCs-exosomal ncRNA在治疗AD中的治疗潜力.
- 在AD治疗中阐明MSCs-exosomal ncRNA的潜在分子机制.
主要方法:
- 在自身免疫性疾病中对外体ncRNA研究的文献综述.
- 对聚焦于介质干细胞 (MSC) 衍生的外体细胞的研究进行分析.
- 对外体内非编码RNAs (ncRNAs) 的分子机制的研究.
主要成果:
- 由介质干细胞 (MSC) 衍生出的外体提供了一种毒性较低,无细胞的治疗替代方案,具有显著的免疫调节作用.
- 外体ncRNA的组织特异性变化与各种疾病有关,包括自身免疫性疾病.
- 外体ncRNAs,特别是miRNAs和lncRNAs,是自身免疫性疾病所影响的生物功能中的关键调解者.
结论:
- MSCs-exosomal ncRNAs代表了对自身免疫性疾病 (AD) 的有希望的治疗途径.
- 了解这些ncRNAs的分子机制对于开发有效的AD治疗至关重要.
- 对外体ncRNA疗法的进一步研究可能会彻底改变自身免疫性疾病的管理.
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