在西班牙裔成年人和老年人中推导认知变化指数
Kevin Duff1, Justin B Miller2, Kim Cobos2
1Layton Aging & Alzheimer Disease Center, Oregon Health and Science University, Portland.
JAMA network open
|September 3, 2024
概括
种族和种族在老年人中随着时间的推移显著影响认知测试表现. 与非西班牙裔白人相比,西班牙裔个体的预测认知结果较差,这突出了包容性模型的必要性.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 老龄化人口的认知能力下降是一个越来越令人担忧的问题,特别是对于阿尔茨海默病的风险.
- 了解种族和种族如何影响认知轨迹对于公平的临床实践和研究至关重要.
- 现有的模型可能无法完全捕捉不同的人口群体认知变化的复杂性.
研究的目的:
- 评估种族和种族对纵向认知测试表现的预测意义.
- 开发和验证统计模型,将人口变量纳入认知衰老研究的基于证据的实践.
主要方法:
- 一项预后研究利用来自健康和衰老大脑研究-健康差异 (HABS-HD) 的24个月随访数据.
- 包括799名50岁以上的西班牙裔和非西班牙裔社区成年人,他们的认知能力不受损害.
- 线性回归模型分析了13个神经心理测试,从基线得分和人口统计因素 (年龄,性别,教育,种族,种族) 预测后续表现.
主要成果:
- 在所有13项认知测试中,基线表现和教育是最强的预测因素.
- 年龄和性别在多个模型中也显著影响了认知随访得分.
- 在13个模型中的10个模型中,种族和种族是显著的预测因素,西班牙裔参与者比非西班牙裔白人参与者预测的后续认知得分较差.
结论:
- 人口统计学变量,包括种族和族裔,大大影响了老年人的认知变化模型.
- 这些发现强调了将种族和种族纳入认知衰老预测模型的必要性.
- 准确预测认知变化对于开发多样化,文化敏感的临床实践和针对全球痴呆危机的试验至关重要.
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