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小细胞食道癌的流行病学,预后因素和生存分析:以外部验证为基础的基于人口的研究
Jiahao Zhu1, Benjie Xu1, Yuanyuan Li1
1Department of Outpatient Chemotherapy, Harbin Medical University Cancer Hospital, Harbin, China.
Biomolecules & biomedicine
|September 3, 2024
概括
小细胞食道癌 (SCEC) 的发病率稳定. 远程转移显著恶化了生存率,而化疗仍然是这种侵袭性食道癌症的关键治疗方法.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 小细胞食道癌 (SCEC) 是一种罕见的,具有不良预后的侵袭性神经内分泌瘤.
- 了解预后因素和治疗对于改善SCEC患者的治疗结果至关重要.
研究的目的:
- 调查影响SCEC预后的因素.
- 评估治疗方法,并开发SCEC生存的预测模型.
主要方法:
- 对SEER注册 (2004-2019) 和中国机构注册 (2012-2022) 的回顾性分析.
- 使用年度百分比变化 (APC) 评估发病率趋势.
- 卡普兰-梅尔和考克斯回归分析的生存,与nomogram发展和验证总生存 (OS) 和癌症特异性生存 (CSS).
主要成果:
- 在2004-2019年间,SCEC发病率趋于平稳 (APC = -1.40%).
- 对OS的独立预后因素包括年龄,远程转移和化疗.
- 远程转移和化疗是CSS的独立因素;名图显示出高的预测准确性.
结论:
- SCEC是一种罕见的恶性瘤,具有侵略性行为和不良预后.
- 远程转移是OS和CSS的显著负面预后因素.
- 化疗仍然是SCEC的主要治疗方式,预测性诺姆图可以帮助临床决策.
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