在COVID-19疫苗接种后的唾液免疫反应
Kenny Nguyen1, Boris Relja1,2, Monica Epperson3
1National Foundation for the Centers for Disease Control and Prevention Inc., Atlanta, GA, United States of America.
PloS one
|September 3, 2024
概括
在Moderna mRNA-1273 COVID-19疫苗接种后检测到针对SARS-CoV-2的唾液抗体 (IgA和IgG). 至少8周的IgG水平保持高,这表明基于唾液的免疫监测有潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 病毒学 病毒学
背景情况:
- mRNA COVID-19 疫苗对于减少严重疾病至关重要.
- 幽默性免疫反应在血液中得到了很好的研究,但在唾液中不那么多.
- 唾液提供了一种非侵入性的方法,用于评估膜免疫在入口点.
研究的目的:
- 为了评估Moderna mRNA-1273 COVID-19疫苗接种后的唾液免疫反应.
- 评估唾液中SARS-CoV-2特定抗体的存在和持续时间.
主要方法:
- 203名参与者接受了mRNA-1273疫苗.
- 唾液样本在多个时间点 (第0,14,28,42,56天) 自行收集.
- 使用酶免疫试验测量了唾液IgA和IgG抗尖蛋白抗体标位.
主要成果:
- 唾液IgA标位在接种疫苗后两周达到峰值,然后下降.
- 唾液IgG标位在第一剂后增加,在第二剂后达到峰值,并且至少在8周内保持升高.
- 根据年龄,性别或种族/种族,没有观察到抗体标位的显著差异.
结论:
- 所有参与者都对mRNA-1273疫苗表现出唾液IgA和IgG免疫反应.
- 唾液是一种可行的媒介,用于评估对COVID-19疫苗接种的免疫反应.
- 需要进一步的研究来确定疫苗接种后2个月的抗体水平.
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