Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Non-invasive brain stimulation in frontotemporal dementia: syndrome-specific signals and priorities for future trials.

Frontiers in aging neuroscience·2026
Same author

Stress-Matching Molecular Bridge and 3D Micro-Nano Array for High-Performance, Lightweight Composite Copper Current Collectors.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Elevated NDUFAF2 expression correlates with poor prognosis and drives metabolic dependency in hepatocellular carcinoma.

Biology direct·2026
Same author

Epicutaneous Exposure to Egg Ovalbumin Highlights a Potential Skin-Gut Immune-Microbiota Axis in Food Allergy Risk.

Journal of agricultural and food chemistry·2026
Same author

Reprogramming the tumor microenvironment with antibody against membrane-proximal AXL to overcome immune checkpoint blockade resistance.

Signal transduction and targeted therapy·2026
Same author

Uncovering causal relationships in single-cell omic studies with causarray.

Briefings in bioinformatics·2026

相关实验视频

Updated: Jul 13, 2026

Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations
10:55

Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations

Published on: December 16, 2017

8.6K

单细胞基因组学的联合轨迹推断使用深度学习与先前混合的混合.

Jin-Hong Du1,2, Tianyu Chen3, Ming Gao4

  • 1Department of Statistics and Data Science, Carnegie Mellon University, Pittsburgh, PA 15213.

Proceedings of the National Academy of Sciences of the United States of America
|September 3, 2024
PubMed
概括

使用变异推断和自编码器的新方法VITAE准确推断细胞发育轨迹. 它提供了强大的不确定性量化,并集成了多个单细胞数据集,用于全面的谱系分析.

关键词:
贝叶斯的等级模型是贝叶斯的等级模型.数据整合数据集成.雅可比式调节器 雅可比式调节器假时间是假时间.一个单细胞测序.

更多相关视频

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
10:12

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Published on: January 10, 2019

18.5K
Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging
09:56

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

6.5K

相关实验视频

Last Updated: Jul 13, 2026

Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations
10:55

Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations

Published on: December 16, 2017

8.6K
Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
10:12

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Published on: January 10, 2019

18.5K
Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging
09:56

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

6.5K

科学领域:

  • 计算生物学 计算生物学
  • 基因组学就是基因组学.
  • 发展生物学 发展生物学

背景情况:

  • 单细胞测序数据分析依赖于轨迹推断来理解细胞分化和发育.
  • 现有的轨迹推断工具往往缺乏强大的统计模型和不确定性量化.

研究的目的:

  • 引入VITAE (Variational Inference for Trajectory by AutoEncoder),这是一个用于强大的细胞轨迹推断的新型统计框架.
  • 通过层次混合模型和变异自动编码器,提高轨迹分析中的解释性和计算效率.

主要方法:

  • 开发了VITAE,集成了一个潜伏的等级混合模型与变化自编码器用于轨迹推断.
  • 实现了同时的轨迹推断和数据集成,以处理生物和技术异质性.
  • 使用后方近似来量化细胞投影的不确定性.

主要成果:

  • 与最先进的方法相比,VITAE在各种拓的合成和真实数据集上表现出更高的性能.
  • 成功应用VITAE共同分析小鼠新皮质单细胞RNA测序数据,揭示了详细的投影神经元系.
  • 展示了VITAE在减少批量效应和在数据集中发现更细微的细胞结构方面的有效性.
  • 验证了VITAE在连续细胞群的综合性多原子分析中的实用性.

结论:

  • 维泰为细胞轨迹推断和数据集成提供了统计严格和计算高效的方法.
  • 该方法增强了对发育过程和血统层次的理解,特别是在复杂的生物系统中.
  • 在分析单细胞和多原子数据方面,VITAE是有效的,提供更高的准确性和减少批量效应.