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响应NIR的可部署和自适应的4D打印骨组织支架.

Saswat Choudhury1, Akshat Joshi1, Akhilesh Agrawal1

  • 1Department of Bioengineering, Indian Institute of Science, C.V. Raman Avenue, Bangalore 560012, India.

ACS applied materials & interfaces
|September 3, 2024
PubMed
概括
此摘要是机器生成的。

这项研究介绍了3D打印的,NIR响应性支架,由聚乙烯-co-trimethylene碳酸盐和聚多巴胺纳米颗粒制成. 这些自适配的支架在关键大小的缺陷中促进了显著的骨再生.

关键词:
在NIR中,NIR是NIR.添加剂制造 添加剂制造 添加剂制造生物材料是一种生物材料.骨架 骨架 脚手架自适应式自适应式自适应式形状记忆 形状记忆 形状记忆

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科学领域:

  • 生物材料科学 生物材料科学
  • 再生医学是一种再生医学.
  • 组织工程是组织工程.

背景情况:

  • 治疗不规则和关键大小的骨缺陷仍然是一个重大的临床挑战.
  • 可部署,自适应的组织支架的最小侵入性植入提供了一个有前途的治疗方法.
  • 开发具有控制形状记忆特性的先进材料对于有效修复骨缺陷至关重要.

研究的目的:

  • 通过使用3D打印,制造出使用聚多巴胺纳米粒子 (PDA) 进行纳米工程的新型近红外 (NIR) 响应和可编程聚酸-协同-三甲基碳酸 (PLMC) 支架.
  • 评估这些PLMC-PDA复合支架的形状恢复,骨质生成潜力和体内骨再生能力.
  • 为了证明在不规则的骨缺陷中脚手架的手术内可部署性和自适配特性.

主要方法:

  • 基于挤出的3D打印被用于制造PLMC-PDA复合式脚手架.
  • 脚手架在NIR照射下进行形状恢复的特征,评估速度,效率和可调性.
  • 通过测量性酸酶 (ALP) 分泌和矿物沉积来评估体外骨质生成潜力.
  • 在体内研究中,在关键大小的子骨缺陷中植入支架,以通过微型计算机断层扫描 (micro-CT) 评估骨再生.
  • 使用子骨,下和牙缺陷的实体模型来确认脚手架的自适配能力.

主要成果:

  • 3D打印的PLMC-PDA支架在NIR照射后表现出极好的 (>99%),快速 (<30秒) 和可调整的形状恢复.
  • 与纯粹的PLMC相比,PLMC-PDA复合物显示出显著增强的骨质生成潜力in vitro,由增加的ALP分泌和矿物沉积证明.
  • 在子头骨缺陷中的体内植入导致PLMC-PDA支架在6周和12周几乎完全恢复骨,超过了整洁的PLMC.
  • 脚手架在低功率的NIR辐射下证明了在不规则的缺陷中有效的手术内自适应.

结论:

  • 开发的3D打印的PLMC-PDA复合支架是NIR响应的,可编程的,并且具有优秀的自适配能力,用于最少的侵入性部署.
  • 这些支架显著增强了体外骨质生成,并在临界大小的缺陷中促进了实质性的体内骨再生.
  • 这些发现证实了这些创新的复合材料支架在治疗复杂和不规则的骨缺陷方面的临床潜力,为骨组织再生提供了一个新的策略.