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索马托斯塔丁可以防止由低氧引起的人体结肠上皮膜透性的增加

Ibrahim Rajput¹, Vazhaikkurichi M Rajendran², Andrew J Nickerson²

¹Department of Surgery, St James's University Hospital, Leeds, United Kingdom.

American journal of physiology. Gastrointestinal and liver physiology

|September 3, 2024

概括

在人类和老鼠结肠模型中,八胺 (OCT) 有效地防止化学缺氧引起的肠道透性和大分子转位的增加. 这一发现表明,OCT可能会在手术期间限制肠道缺血,降低败血症风险.

科学领域:

胃肠病学胃肠病学
生理学生理学生理学
药理学药理学是指药理学的学科.

背景情况:

中肠缺血会提高肠道的透性和细菌的转移.
由2,4-丁烯醇 (DNP) 诱导的化学缺氧激活了人类结肠中的中间导电性K+ (IK) 通道,增加了半细胞突变导电性 (G_S).
索马托斯塔丁 (SOM) 抑制IK通道并减轻缺氧引起的G_S增加.

研究的目的:

调查合成SOM模拟物octreotide (OCT) 是否可以防止人类结肠中缺氧诱导的对细胞突变导电性 (G_S) 的增加.
评估OCT对大肠小鼠缺氧诱导的总上皮质导电性 (G_T) 和大分子透性 (FITC-dextran 4000) 的增加的影响.

主要方法:

隔离的人体结肠片段用2,4-丁二 (DNP) 治疗,以诱导化学缺氧,有或没有SOM或OCT.
测量了对细胞突变导电性 (G_S).
隔离的老鼠远肠被暴露在DNP中,有或没有OCT预处理,以评估总上皮电导率 (G_T) 和FITC-dextran 4000透性的变化.

主要成果:

在人类结肠中,DNP显著增加了52%的G_S.
无论是SOM还是OCT,都同样防止了人类结肠中DNP诱导的G_S增加.
在老鼠结肠中,DNP增加了G_T18%,FITC-dextran 4000的透率增加了43%;OCT预处理完全消除了这些影响.

结论:

奥克特雷奥提德有效地防止了对人体和老鼠结肠中双细胞和巨分子透性的缺氧诱导的增加.
在腹部手术期间,OCT可以减轻因缺血引起的肠道过性.
这种保护作用可以减少细菌和内毒素转位,从而降低败血症的风险.

关键词:

结肠透性结肠透性介质性缺血症介质性缺血症准细胞导电性准细胞导电性通道是的通道.索马托斯塔丁类酸是什么

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