更年期类型与轻度认知障碍之间的关联:REDLINC XII研究
María T Espinoza1, Juan E Blümel2, Peter Chedraui3
1Unidad de Ginecología Obstétrica, Clínica Los Ángeles, Cochabamba, Bolivia.
Maturitas
|September 3, 2024
概括
无论年龄如何,手术性更年期都会增加轻度认知障碍 (MCI) 的风险. 然而,已使用更年期激素治疗的女性显示MCI的风险降低. 需要进一步的研究.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 更年期对女性来说是一个重要的生命过渡,对认知健康有影响.
- 了解更年期类型 (自发与外科手术) 对认知功能的差异影响至关重要.
研究的目的:
- 调查更年期的类型 (自发或手术) 与轻度认知障碍 (MCI) 的患病率之间的关联.
主要方法:
- 这是一项涉及9个拉丁美洲国家的1185名绝经后妇女的横截面观察研究.
- 收集的数据包括社会人口统计因素,临床病史,家族痴呆史和使用蒙特利尔认知评估 (MoCA) 工具进行认知评估.
- 使用后勤回归分析来确定与MCI相关的因素.
主要成果:
- 与自发更年期相比,经过手术更年期的女性的MoCA得分较低 (p < 0.001).
- 手术性更年期与MCI风险增加显著相关 (OR1.47,95%CI:1.01-2.16).
- 曾经使用过更年期激素治疗 (OR 0.33,95% CI:0.21-0.50) 和12年以上的教育 (OR 0.21,95% CI:0.14-0.30) 与较低的MCI风险有关.
结论:
- 手术性更年期,无论年龄如何,都与更高的认知能力下降的易感性有关.
- 在比较40岁前后自发更年期时,没有观察到MCI的风险增加.
- 绝经期使用激素治疗与MCI风险降低有关,需要进一步调查.
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