在胎儿后代的发育性毒性的特征,由怀孕期间的乙氨基暴露引起的
Ze Chen1, Xiaoxiang Sun2, Yi Liu2
1Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China.
Ecotoxicology and environmental safety
|September 3, 2024
概括
在小鼠中产前乙氨基暴露 (PAcE) 导致妊娠不良后果和胎儿多器官发育毒性. 高剂量,末期和重复暴露加剧了这些影响,特别是在男性中.
科学领域:
- 环境毒理学环境毒理学
- 发育生物学是发展生物学.
- 生殖毒理学 生殖毒理学
背景情况:
- 乙氨基 (APAP) 是一种常见的 analgesic 和 antipyretic 在怀孕期间使用.
- APAP是一种新兴的环境污染物,可能对胎儿发育产生不利影响.
- 关于APAP在胎儿发育中的毒性特征的研究有限.
研究的目的:
- 系统地研究乙氨基对胎儿发育有毒性的特征.
- 分析产前乙氨基暴露 (PAcE) 对怀孕结果和胎儿发育的影响.
- 确定不同暴露水平,时间和APAP疗程对胎儿健康的影响.
主要方法:
- 怀孕的小鼠接受了APAP的不同剂量 (100或400毫克/公斤/天) 和持续时间 (第二或第三季度,单次或多次疗程).
- 评估怀孕结果,孕产妇和胎儿的血液表型.
- 评估胎儿小鼠的多器官形态和功能发展.
主要成果:
- PAcE导致妊娠不良结果增加,并改变了母体和胎儿的血液表型.
- 抑制海马突触和性激素合成,骨质生/性激素发育;增强肝脂质合成,脏增生,上腺类固醇生成.
- 诱导胎儿海马,骨,脏和软骨的病理变化,男性胎儿和特定暴露条件显示出更大的敏感性.
结论:
- 在胎儿小鼠中,PAcE诱导多器官发育毒性和功能性改变.
- 该研究阐明了APAP发育毒性的特征,包括器官特异性敏感性和影响因素.
- 这些发现加深了对APAP在怀孕期间的风险的理解.
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