在先进的非小细胞肺癌中,在初始免疫疗法后,瘤进展的治疗选择:现实世界的研究
Ying Li1, Junfeng Zhao2, Ruyue Li3
1Department of Respiratory Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, 250000, China.
在晚期非小细胞肺癌 (NSCLC) 瘤进展后继续免疫治疗可以改善存活率. 将免疫疗法与抗血管原治疗结合起来,为这些患者提供了最好的结果.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 非小细胞肺癌 (NSCLC) 是一种非小细胞肺癌.
背景情况:
- 在瘤进展后,对于晚期非小细胞肺癌 (NSCLC) 患者的持续免疫治疗存在争议.
- 了解生存结果和最佳组合疗法后进展至关重要.
研究的目的:
- 探索在晚期NSCLC中持续免疫治疗后的生存结果.
- 为了确定最有效的组合疗法NSCLC患者经历瘤进展在免疫治疗.
主要方法:
- 对507名接受免疫治疗并进展的NSCLC患者的回顾性分析.
- 患者被分为"免疫组合" (持续免疫疗法与额外治疗) 和"无免疫"组.
- 使用倾向性得分匹配,然后评估无进展生存期 (PFS) 和总生存期 (OS).
主要成果:
- 免疫组合组显示PFS和OS明显优于非免疫组后进展.
- 在免疫组合组中,接受免疫疗法加抗血管原治疗的患者表现出比接受免疫疗法加化疗的患者更好的PFS和OS.
- 观察到统计学意义 (总体比较P<0.001,PFS子组P=0.017).
结论:
- 在免疫治疗中进展的高级NSCLC患者仍然可以从进一步的治疗中受益.
- 将免疫疗法与抗血管原治疗结合起来似乎是改善这种患者群体生存率的最有效策略.
更多相关视频
10:29Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence
Published on: August 14, 2019
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
相关概念视频
Tumor Immunotherapy
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
