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Transthoracic Echocardiography in Mice
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猫的左心房分数缩短:两个心声回声图视图之间的比较
A Machado1, C Partington1, J Silva1
1Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, England, United Kingdom.
概括
两种用于测量猫的左心房分数缩短 (LAFS%) 的回声心脏学方法的一致性较差,不应互换使用. 这两种方法都与大动脉根运动相关,但与大动脉流动无关.
科学领域:
- 兽医心脏病学 兽医心脏病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
- 猫类心脏病 猫类心脏病
背景情况:
- 左心房分数缩短 (LAFS%) 是猫的左心房缩功能的一个关键指标,预测了多变性心肌病 (HCM) 和心脏死亡率.
- 对于LAFS%的测量存在两种常用的方法:M模式右侧侧侧短轴视图 (LAFS%RPSA-MM) 和二维右侧侧侧长轴四腔视图 (LAFS%RPLA-2D).
研究的目的:
- 在猫中评估LAFS%RPSA-MM和LAFS%RPLA-2D之间的协议.
- 评估两种LAFS%方法与左心室缩性表现指标的相关性.
主要方法:
- 一项追溯病例对照研究,涉及117只猫 (40只对照,41只无症状HCM,36只有症状HCM).
- 使用布兰德-阿尔特曼分析来确定LAFS%RPSA-MM和LAFS%RPLA-2D之间的协议.
- 相关性分析检查了与前方大动脉流动,左心室分数缩短和大动脉根运动的关联.
主要成果:
- 虽然方法之间的平均LAFS%值相似 (P=0.8),但Bland-Altman分析显示了广泛的一致性,表明互换性不佳.
- 在LAFS%方法和大动脉根运动之间观察到良好的相关性 (r=0.78对于LAFS%RPSA-MM,r=0.71对于LAFS%RPLA-2D).
- 发现与左心室分数缩短有相当的相关性 (r=0.31对于LAFS%RPSA-MM,r=0.29对于LAFS%RPLA-2D),与大动脉流量指数没有相关性.
结论:
- 猫的LAFS%RPSA-MM和LAFS%RPLA-2D之间很少有一致性,这排除了它们的互换性使用.
- 这两种心声回声学方法都与大动脉根运动有很强的相关性,这表明它在间接评估左心房功能的有用性.
相关概念视频
Chambers of the Heart
The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
Deoxygenated blood from the body is received in the right...
Heart Sounds
Heart sounds are generated by the turbulence in blood flow due to the closing of heart valves. These sounds are best perceived slightly away from the valves, where the blood flow disseminates the sound.
Auscultation is the process of listening to these internal body sounds using a stethoscope. The heart produces four types of sounds, but only two—S1 and S2—can usually be heard with a stethoscope.
S1, also known as the "lub" sound, is caused by the closure of atrioventricular (A-V) valves at the...
Auscultation is the process of listening to these internal body sounds using a stethoscope. The heart produces four types of sounds, but only two—S1 and S2—can usually be heard with a stethoscope.
S1, also known as the "lub" sound, is caused by the closure of atrioventricular (A-V) valves at the...

