分离性发作在大脑上的印记
S G Mueller1, N Garga2, P Garcia3
1Center for Imaging of Neurodegenerative Diseases, VAMC, San Francisco, CA, USA; Dept of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
NeuroImage. Clinical
|September 3, 2024
概括
分离性发作 (DS) 在特定的大脑状态期间涉及情绪超连接. 大脑干网络的缩可能导致DS患者的体化和运动症状.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 分离性 (DS) 与情绪控制与其他专门的大脑区域之间的功能连接性增加有关,称为情绪超连接性.
- 这种超连接性是DS患者的神经成像检测结果的一致性.
研究的目的:
- 使用动态静止状态fMRI和脑干体积测量来描述DS相关的情绪超连接性.
- 要确定情感超连接是否依赖于状态.
- 研究神经调节系统子网络缩对情感超连接性的影响.
主要方法:
- 13名患有分裂性发作 (PDS) 的人和15名对照人接受了结构性和功能性MRI.
- 基于变形的形态测量评估了大脑体积的损失,重点是脑干结构.
- 动态fMRI分析,图形和层次分析确定了9个不同的大脑状态.
主要成果:
- 情绪上的超连接性仅限于大脑状态6,这在PDS中比对照者更长时间,并且在全球范围内更连接.
- 状态6连接性与体化,抑郁,PTSD严重程度和解离相关.
- 在PDS中观察到脑干调节和情绪运动子网络的缩,与第6状态的持续时间和体化严重程度相关.
结论:
- 与DS相关的情绪超连接性是6状态情节的特征.
- 调节子网络中的缩可能促进异常相互作用,有助于DS的体化.
- 情绪运动子网络的缩可能导致DS中观察到的运动症状,这表明这种情况的神经生理基础.
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