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在骨关节炎中,皮下脂肪的双相作用

Songkai Yue¹, Ganggang Zhai¹, Siyu Zhao¹

¹Department of Orthopedics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan University People's Hospital, Zhengzhou 450003, China.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

|September 3, 2024

概括

皮下脂肪 (IPFP) 在骨关节炎 (OA) 中起着双重作用,可能保护关节,但也通过炎症因素促进疾病的进展. 了解IPFPFP的理解

科学领域:

整形外科整形外科整形外科
类风湿病学类风湿病学
细胞生物学细胞生物学

背景情况:

骨关节炎 (OA) 是一种退行性关节疾病,影响所有关节组织,包括底脂肪 (IPFP).
膝盖中的大型脂肪组织IPFP可能通过吸收冲击并释放信号分子来影响关节健康.
之前的研究表明,IPFP在OA病变发生过程中具有复杂的双相作用.

研究的目的:

审查目前关于IPFP在骨关节炎中的作用的研究.
阐明IPFP影响OA进展的机制.
探索针对OA治疗的IPFP的新型治疗策略,并讨论在全膝关节关节整形术期间的管理.

主要方法:

对IPFP和OA最近研究的文献综述.
分析涉及IPFP衍生细胞因子和基因的分子机制.
讨论IPFP衍生细胞疗法 (半酶体干细胞,外体细胞) 和外科手术方面的考虑.

主要成果:

IPFP释放出促炎和促消化因素,这些因素有助于软骨退化和OA进展.
来自IPFP的介质干细胞和外体细胞显示出降低疼痛和预防骨关节炎进展的潜力.
IPFP表现出双相效应,表明在OA中存在上下文依赖的角色.

结论:

在骨关节炎中,IPFP具有显著的,多方面的作用,既是潜在的保护因素,也是疾病的驱动因素.
针对IPFP衍生因子或利用IPFP衍生细胞为OA干预提供了有希望的途径.
在全膝关节整形术期间IPFP的最佳管理需要进一步调查.

关键词:

皮下脂肪子的脂肪子介质细胞干细胞介质细胞干细胞骨关节炎是一种骨关节炎.单细胞测序是一个单细胞的测序.整体膝关节关节整形手术

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