住房干预的随机对照试验,以减少儿童对内分泌破坏性化学物质的暴露
Alan J Fossa1, Katherine E Manz2, George D Papandonatos3
1Brown University School of Public Health, Department of Epidemiology, Providence, Rhode Island, United States of America.
Environment international
|September 3, 2024
概括
家庭干预措施减少了儿童对内分泌干扰化学物质 (EDC) 的暴露. 一项住房干预措施降低了幼儿,特别是黑人或非裔美国儿童的酸盐和 perfluoroalkyl 物质 (PFAS).
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 儿科 儿科 儿科
背景情况:
- 关于家庭干预措施减少儿童内分泌干扰化学物质 (EDC) 暴露的研究有限.
- 内分泌干扰化学物质 (EDC) 对儿童发育和健康构成风险.
- 家庭灰尘和环境污染是EDC的重要暴露途径.
研究的目的:
- 评估住房干预措施在减少幼儿EDC暴露方面的有效性.
- 评估涂料稳定和灰尘减轻对甲酸盐和 perfluoroalkyl 物质 (PFAS) 水平的影响.
- 调查干预对人口群体的影响差异.
主要方法:
- 一项随机对照试验 (HOME研究) 的二次分析,涉及俄俄州辛辛那提的250名儿童.
- 家庭接受住房干预 (油漆稳定,防尘) 或受伤预防教育.
- 在不同时间点,在尘埃,尿液和血清中测量了有机酸盐 (OPEs),酸盐和PFAS.
主要成果:
- 住房干预与尿道DEHP代谢物减少23%有关.
- 每项协议分析显示,尿路MBZP减少了34%.
- 在黑人或非裔美国儿童中,干预措施显著降低了包括PFNA (-42%) 在内的几个PFAS的血清度.
结论:
- 家庭干预措施包括涂料稳定和灰尘减轻可以有效地减少儿童对某些酸盐和PFAS的暴露.
- 这些发现表明,对黑人或非裔美国儿童有潜在的益处,需要进一步调查.
- 需要对持续的,定制的住房干预措施进行更大规模的研究,以确认和扩展这些结果.
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