过度腹部肥胖对精神分裂症中大脑微观结构异常的影响
Shinichi Yamada1, Shun Takahashi2, Daniel Keeser3
1Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilians University (LMU), Munich, Germany; Department of Neuropsychiatry, Wakayama Medical University, Wakayama, Japan.
肥胖与精神分裂症 (SZ) 有关,较高的腹部肥胖与较低的白质完整性,皮质厚度降低和SZ患者认知功能恶化有关. 这些发现突显了精神分裂症患者和肥胖患者的大脑差异.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 肥胖和精神分裂症 (SZ) 有着重要的联系,但潜在的大脑机制仍然不清楚.
- 特别是腹部肥胖症在心理健康研究中越来越令人担忧.
研究的目的:
- 为了研究不同程度的腹部肥胖症的精神分裂症患者的大脑结构差异.
- 探索肥胖,大脑结构和精神分裂症的认知功能之间的关系.
主要方法:
- 在低腰围 (SZ-LWC) 和高腰围 (SZ-HWC) 的精神分裂症患者和健康对照者 (HC) 中,比较白质完整性 (微分异性) 和皮质厚度.
- 利用基于通道的空间统计和Free Surfer进行脑成像分析.
- 评估认知表现和甘油三水平.
主要成果:
- 与健康对照者相比,腰围较高的精神分裂症患者 (SZ-HWC) 在右叶和岛屿皮层中显示出明显较低的白质分数异构和平均皮质厚度.
- 与健康对照组相比,腰围较低的精神分裂症患者 (SZ-LWC) 也表现出较低的区域白质分数异构.
- 两组之间没有发现皮层下体积的显著差异.
- SZ-HWC组表现出较差的认知表现和较高的甘油三水平.
结论:
- 精神分裂症患者的过度腹部肥胖与微观结构白质异常和皮质厚度降低有关.
- 这些神经生物学变化与精神分裂症中神经认知缺陷相关.
- 这些发现强调了在精神分裂症管理中解决肥胖问题的重要性,以潜在地减轻大脑结构变化和认知衰退.
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