Vulvar Paget 的疾病:一个基于人群的癌症注册表描述性研究
Charlée Nardin1, Pauline Fattet2, Rajeev Ramanah2
1Department of Dermatology, University Hospital, Besançon, France; Inserm 1098 RIGHT, University of Franche Comté, Besançon, France.
Journal of gynecology obstetrics and human reproduction
|September 3, 2024
概括
Vulvar Paget's Disease (VPD) 经常复发,特别是在5年后. 手术后的辅助疗法显著改善了这种罕见的皮肤癌的无复发生存率.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- Vulvar Paget 的疾病 (VPD) 是一种罕见的皮肤癌.
- 虽然预后一般是好的,但高复发率会对生活质量产生负面影响.
研究的目的:
- 调查VPD的流行病学和临床特征.
- 专注于法国法兰克县地区的诊断.
主要方法:
- 对1981年至2021年间诊断的VPD病例进行了回顾性研究.
- 包括来自Doubs癌症注册表的数据.
- 对临床,组织学,治疗和随访数据的分析.
主要成果:
- 21名患者被诊断患有VPD (19名内皮层,2名侵入性).
- 诊断时的中位数年龄为72岁;诊断的中位数时间为24个月.
- 在29%的患者中发现了相关的癌症.
- 5年复发率为26%,随着随访时间的延长,复发率增加到42%.
- 不完整的手术切除 (100%) 与86%的复发有关,而局部治疗的复发率为20%.
- 术后辅助疗法显著改善了无复发生存率 (p < 0.001).
结论:
- 手术后复发的VPD是常见的,通常发生在5年后.
- 长时间的患者随访是必不可少的.
- 手术后的辅助治疗显著提高了无复发的生存率.
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