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相关概念视频

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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相关实验视频

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年龄和视觉皮层抑制:TMS-MRS研究

Molly Simmonite1,2, Dalia Khammash2, Katherine J Michon2

  • 1Department of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI 48109, United States.

Cerebral cortex (New York, N.Y. : 1991)
|September 3, 2024
PubMed
概括

年长的成年人表现出视觉皮层抑制的减少,通过配对脉冲跨脑磁刺激测量. 这种下降与视觉皮层的GABA+水平较低相关,这表明与年龄相关的抑制神经传递的变化.

关键词:
老化的老化 衰老的老化加玛-氨基黄油酸 (Gamma-aminobutyric acid) 是一种胺酸.磁共振光谱学 磁共振光谱学跨的磁性刺激

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相关实验视频

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科学领域:

  • 神经科学是一个神经科学.
  • 人体生理学 人体生理学

背景情况:

  • 双脉冲横磁性刺激 (ppTMS) 已建立用于研究运动皮层抑制.
  • 之前的工作扩展了ppTMS,通过测量烯大小来评估视觉皮层抑制.
  • 衰老与大脑功能的变化有关,但视觉皮层抑制机制仍然不太了解.

研究的目的:

  • 为了研究初级视觉皮层抑制的与年龄相关的差异.
  • 检查视觉皮层抑制和GABA+水平在初级视觉皮层之间的关系.
  • 为了确定GABAergic机制是否是视觉皮层抑制与年龄相关的变化的基础.

主要方法:

  • 在年轻和老年人中使用ppTMS评估视觉皮层抑制.
  • 在初级视觉皮层使用磁共振光谱学 (MRS) 测量GABA+度.
  • 与MRS衍生的GABA+水平相关的ppTMS抑制措施.

主要成果:

  • 老年人表现出明显较低的ppTMS测量视觉皮层抑制.
  • 在老年人中,未经校正的GABA+水平较低,但组织校正的GABA+与年龄保持不变.
  • 在ppTMS抑制和组织纠正的GABA+之间发现了显著的正相关性.

结论:

  • 研究结果表明,主要视觉皮层内的抑制功能与年龄相关的下降.
  • 这种相关性支持GABAergic神经递质在视觉皮层抑制中的作用,类似于运动皮层的发现.
  • ppTMS是评估人类视觉皮层的抑制功能和GABAergic机制的一种可行的工具.