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胃绕道手术后的代谢适应:来自2年观察性研究的结果
Fathimath Naseer1, Shu-Dong Zhang2, Alexander D Miras2
1Nutrition Innovation Centre for Food and Health (NICHE), Ulster University, Coleraine, BT52 1SA, United Kingdom.
International journal of obesity (2005)
|September 3, 2024
概括
胃绕道手术 (GBP) 患者经历了代谢适应,基本代谢率 (BMR) 降低,这可能有助于长期减肥. 这种适应性类似于12个月后体重稳定的个体.
科学领域:
- 代谢适应和减肥外科手术
- 减肥的生理学 减肥的生理学
- 身体组成和新陈代谢
背景情况:
- 代谢适应,基底代谢率 (BMR) 的降低,不能由身体组成的变化来解释,可以阻碍减肥.
- 目前尚不清楚代谢适应是否发生并在胃旁路手术 (GBP) 后持续存在.
研究的目的:
- 为了研究在GBP之后患者的代谢适应.
- 为了比较不由身体组成解释的BMR变化,GBP患者与体重稳定的对照组进行了比较.
主要方法:
- 31名英患者和32名体重稳定的对照患者在手术前和手术后3,12和24个月被评估.
- 基础代谢率 (BMR) 通过间接热量计测量,通过DXA测量身体成分.
- 使用线性回归分析来评估代谢适应.
主要成果:
- GBP患者显著减肥,主要是脂肪质量 (FM),随着手术后24个月的BMR降低与对照组相似.
- 在所有减肥和维护阶段观察到代谢适应.
- 从12个月开始,GBP患者的代谢适应程度与体重稳定的组相比较.
结论:
- GBP可能涉及一种生物机制,减弱了手术后预期的BMR减少.
- 这种减轻可能有助于成功的长期减肥维持在英患者.
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