基于计算机断层扫描对腹腔大动脉动脉瘤患者周围血管脂肪组织的评估
Daniel Ginzburg1, Sebastian Nowak1, Ulrike Attenberger1
1Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Scientific reports
|September 3, 2024
概括
通过CT扫描检测到的周周血管脂肪组织 (PVAT) 密度变化表明腹腔大动脉动脉瘤 (AAA) 患者的炎症. 这些发现表明,PVAT CT密度变化可以作为AAA中血管炎症的非侵入性标志物.
科学领域:
- 放射学和医学成像学 医学成像学
- 血管外科 血管外科
- 生物医学工程 生物医学工程
背景情况:
- 腹腔大动脉动脉瘤 (AAA) 与炎症有关.
- 周血管脂肪组织 (PVAT) 在血管炎症中起作用.
- 需要对AAA相关炎症进行非侵入性成像标记.
研究的目的:
- 在计算机断层扫描 (CT) 中调查周围血管脂肪组织 (PVAT) 变化,作为腹腔大动脉动脉瘤 (AAA) 患者炎症的潜在标志物.
- 为了比较AAA患者和对照者之间的PVAT密度,以及AAA患者内的动脉瘤和非动脉瘤部分之间的PVAT密度.
主要方法:
- 从AAA患者和100个对照的100个腹部CT扫描的回顾性分析.
- 人工智能 (AI) 协助对大动脉和周围PVAT进行细分.
- 以霍恩斯菲尔德单位 (HU) 测量PVAT密度,在离大动脉壁的不同距离.
- 规范化衰减措施的计算:HU差 (HUΔ) 和脂肪衰减比 (HUratio).
主要成果:
- 个人间比较:AAA患者与对照人群相比,显著更高的HUΔ和更低的HUratio (分别为p=0.006和p=0.004).
- 个体内比较:AAA患者的动脉瘤段比非动脉瘤段显著更高的HUΔ和更低的HUratio (p<0.001).
- 这些结果表明与AAA相关的PVAT密度变化明显.
结论:
- 周血管脂肪组织密度的改变在患有腹腔大动脉动脉瘤的患者中是明显的.
- 基于CT的PVAT密度指标 (HUΔ和HUratio) 显示了在AAA中作为血管和周血管炎症的非侵入性成像标志物的潜力.
- 需要进一步的研究来验证这些发现及其临床实用性.
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