过重和维生素D缺乏在患有刺激性肠综合征的患者中很常见 - 一项横截面研究
Bodil Roth1, Bodil Ohlsson2,3
1Department of Internal Medicine, Skåne University Hospital, Jan Waldenströms Street 15, floor 5, Malmö, 205 02, Sweden.
BMC gastroenterology
|September 3, 2024
概括
刺激性肠综合征 (IBS) 患者经常出现体重和体重指数 (BMI) 的增加,与健康人相比,维生素D水平较低. 在IBS中,肠外症状与更高的BMI和降低的铁含量有关.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 临床研究 临床研究
背景情况:
- 刺激性肠综合征 (IBS) 是一种普遍存在的疾病,其起源不明.
- 营养不足和超重是IBS的潜在危险因素.
- 这项研究旨在比较IBS患者和对照者的体重和微量营养素水平.
研究的目的:
- 调查IBS患者和健康对照者之间体重和循环微量营养素水平的差异.
- 探索体重,BMI,特定微量营养素和IBS患者的症状负担之间的相关性.
主要方法:
- 一项涉及IBS患者和健康志愿者的横截面研究.
- 数据收集包括饮食日记,症状问卷 (罗马IV,IBS-SSS,VAS-IBS),人体测量和血液分析,用于CRP,科巴胺,叶酸,铁,TIBC和25-OH维生素D.
- 统计分析涉及到针对错误发现率 (FDR) 调整的通用线性模型.
主要成果:
- 与对照组相比,IBS患者年龄较大,体重和BMI明显高;48.1%的IBS患者超重/肥胖.
- 在IBS患者中观察到高C反应蛋白 (CRP) 和可巴胺,叶酸水平较低.
- IBS患者报告了较低的蔬菜,乳制品和谷物摄入量. 维生素D水平没有显著差异,但在超重的IBS患者中较低. 肠外症状与较高的BMI和较低的铁含量相关.
结论:
- IBS患者经常表现出超重或肥胖以及较低的维生素D水平.
- 在IBS中,显著的肠外症状与增加的BMI和降低的铁状况有关.
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