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临床概况,微生物学和感染性内心炎的结果治疗大动脉置换:一个多中心病例控制研究

Håvard Dingen^1,2, Stina Jordal², Sorosh Bratt^3,4

¹Department of Internal Medicine, Stord Hospital, Stord, Norway.

BMC infectious diseases

|September 3, 2024

概括

大动脉感染性内心炎 (IE) 在大动脉置换 (AVR) 后显著增加了短期和长期死亡风险. 识别和治疗可修改的风险因素对于改善IE患者的存活率至关重要.

科学领域:

心脏病学心脏病学
传染性疾病传染性疾病
外科手术的结果

背景情况:

大动脉感染性内心炎 (IE) 由于高发病率和死亡率而构成重大挑战.
了解接受大动脉置换 (AVR) 的IE患者的临床形状和死亡预测因素至关重要.

研究的目的:

为了比较IE患者接受AVR的临床特征,风险因素和死亡预测因素,与非传染性膜心脏病的对照组进行比较.
评估IE对AVR后短期和长期存活率的影响.

主要方法:

一项多中心病例控制研究,涉及170名IE患者和677名在2008年至2013年期间在斯堪的纳维亚地区接受AVR治疗的对照.
考克斯回归模型被用来估计死亡率的原始和调整的危险比率 (HR).

主要成果:

IE患者的基线人口结构类似,但AVR后的短期 (HR 2.86) 和长期 (HR 2.03) 死亡率较高.
对IE的独立风险因素包括男性性别,之前的手术,体重不足,功能衰竭和C型肝炎.
在IE患者中,长期死亡率的预测因素包括慢性肺炎,体重不足,功能衰竭,中枢参与和中炎. 黄金葡萄球菌和肠球菌对早期和长期死亡率产生了不同的影响.

结论:

传染性内心炎显著增加了在动脉置换后短期和长期死亡的风险.
及时识别和治疗可改变的IE风险因素,以及缓解低生存预测因素,对于改善患者的治疗结果至关重要.

关键词:

大动脉门的更换案例控制研究研究.肠球菌 (Enterococci) 是一种内肠球菌.传染性内心炎是一种感染性内心炎.死亡率死亡率死亡率预后预后预测预测黄金葡萄球菌黄金葡萄球菌

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