在荷尔蒙激素激素释放激素激活器触发后,与人类胆管性淋巴激素重启可能是空卵泡综合征的解决方案吗?
Zeynep Ece Utkan Korun1, Ayşen Yücetürk1, Özge Karaosmanoğlu1
1Acıbadem Maslak Hospital Assisted Reproductive Technologies Unit, İstanbul, Turkey.
Turkish journal of obstetrics and gynecology
|September 4, 2024
概括
人体胆管激素 (hCG) 的重新触发可以在激发性激素释放激素激活剂 (GnRHa) 后出现空卵泡综合征的情况下防止试管婴儿周期的取消. 这种方法保持了可比的卵细胞成熟度和活产率,尽管卵子利用率可能下降.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
- 卵巢刺激协议 卵巢刺激协议
背景情况:
- 空卵泡综合征 (EFS) 是试管婴儿周期中罕见的并发症.
- 激素释放激素激素激素 (GnRHa) 触发物有时会导致EFS,其特征是缺少卵细胞.
- 这就需要采用替代策略来防止循环取消.
研究的目的:
- 为了研究人类胆性淋巴激素 (hCG) 作为救援触发剂在经历GnRHa触发后EFS的患者中的有效性.
- 评估hCG重新触发对卵细胞产量,成熟度和随后怀孕结果的影响.
主要方法:
- 在415名试管婴儿患者的回顾性队列分析中,使用GnRH主动激素激发的对抗剂协议.
- 识别和分析经历EFS的病例 (1.4%).
- 与EFS患者和没有EFS患者之间的结局的比较,包括卵细胞检索,胚胎发育和怀孕率.
主要成果:
- 空毛囊综合征 (EFS) 发生在1.4%的患者中 (415人中有6人).
- 患有EFS的患者表现出较低的黄素化激素水平,较少的卵细胞,胚胎和母细胞囊,导致卵细胞利用率降低.
- 尽管存在这些差异,但在hCG重新触发和冷胚胎移植后,EFS和非EFS组之间的怀孕和活产率是可比的.
结论:
- 人体胆性腺激素 (hCG) 的重新触发是一种可行的策略,以防止在GnRHa触发后在EFS的超响应者中取消周期.
- 虽然卵细胞利用率可能较低,但卵细胞成熟度和妊娠结果仍然相似.
- 在HCG重新触发后的冷胚胎移植显示了类似的阳性妊娠测试结果和活产率,提供了一个成功的替代方案.
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