Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Membrane Fluidity01:23

Membrane Fluidity

151.7K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
151.7K
What are Lipids?01:31

What are Lipids?

7.5K
Lipids function as structural components of cellular membranes, in addition to acting as energy reservoirs and signaling molecules. They are thus crucial to all living organisms.  The three biologically important classes of lipids are triglycerides, phospholipids, and steroids.
Non-Polar and Hydrophobic Characteristics of Lipids
Lipids are a structurally and functionally diverse group of hydrocarbons—compounds consisting of carbon and hydrogen atoms. The carbon-carbon and...
7.5K
Synthesis of Phosphatidylcholine in the ER Membrane01:27

Synthesis of Phosphatidylcholine in the ER Membrane

3.0K
The ER synthesizes lipids for building cell membranes and performing cellular functions such as energy storage and signaling. The lipid synthesis machinery embedded in the ER membrane primarily collects all reactants from the cytosol. Following synthesis, the secretory pathway and the ER contact sites distribute these lipids to other cellular organelles. Additionally, the energy-rich triacylglycerides are transported from the ER via lipid droplets.
The major components of all eukaryotic cell...
3.0K
Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

7.2K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
7.2K
Membrane Lipids01:32

Membrane Lipids

23.1K
Lipids are an essential component of all biological membranes. The average lipid content in mammalian membranes is 50%, though it can be as low as 20% in the inner mitochondrial membrane or as high as 80% in the myelin sheath present around the nerve cells.
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...
23.1K
Structure of Lipids03:38

Structure of Lipids

87.4K
Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
87.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A Raman spectral marker for the iso-octyl chain structure of cholesterol.

Analytical science advances·2024
Same author

The Raman Active Vibrations of Flavone and Quercetin: The Impact of Conformers and Hydrogen Bonding on Fingerprint Modes.

The journal of physical chemistry. A·2023
Same author

The Raman Active Vibrational Modes of Anthraquinones.

Astrobiology·2022
Same author

Effects of Conformational Variation on Structural Insights from Solution-Phase Surface-Enhanced Raman Spectroscopy.

The journal of physical chemistry. B·2021
Same author

Point-of-care device to diagnose and monitor neonatal jaundice in low-resource settings.

Proceedings of the National Academy of Sciences of the United States of America·2017
Same author

Our First and Next Decades at ACS Nano.

ACS nano·2017

相关实验视频

Updated: Jun 14, 2025

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

2.2K

脂膜中的胆固醇形态结构

Kyra R Birkenfeld1, Tia N Gandhi1, Mathieu L Simeral1

  • 1Department of Physics & Astronomy, Rice University, Houston, Texas 77005, United States.

The journal of physical chemistry. A
|September 4, 2024
PubMed
概括

密度函数理论 (DFT) 的计算揭示了胆固醇.

科学领域:

  • 生物化学 生化学
  • 分子生物物理学 分子生物物理学
  • 计算化学的计算化学

背景情况:

  • 胆固醇对于生物膜特性,如秩序和透性至关重要.
  • 其精确的分子机制仍在研究中.
  • 密度函数理论 (DFT) 能够对分子振动进行详细的光谱分析.

研究的目的:

  • 用DFT计算来解释胆固醇的拉曼光谱.
  • 为了确定胆固醇在脂膜中的结构分布.
  • 为了阐明胆固醇与脂链的相互作用.

主要方法:

  • 密度函数理论 (DFT) 对胆固醇合规者的计算.
  • 对10个胆固醇结构的独特低频拉曼光谱的识别.
  • 将实验光谱与DFT衍生的类型相匹配,以测量囊泡中的结构分布.

主要成果:

  • 识别了10种独特的胆固醇符合者,具有独特的拉曼光谱.
  • 测量了脂 (PL) 囊中的胆固醇结构分布.
  • 观察到与和的PL链的同位素链对齐,与不和的PL链的热分布.

结论:

更多相关视频

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer SALB Method
09:38

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer SALB Method

Published on: December 1, 2015

14.9K
Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
12:18

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Published on: August 3, 2021

3.5K

相关实验视频

Last Updated: Jun 14, 2025

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

2.2K
Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer SALB Method
09:38

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer SALB Method

Published on: December 1, 2015

14.9K
Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
12:18

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Published on: August 3, 2021

3.5K
  • 胆固醇的异构八链在它的上部表现出刚性,类似于它的环.
  • 结果支持胆固醇对PL膜的模板效应.
  • 将水分子纳入DFT可能会增强未来的光谱拟合.